Evaluating the role of biomarkers for cardiovascular risk prediction: Focus on CRP, BNP and urinary microalbumin

Abigail May; Thomas J. Wang

doi:10.1586/14737159.7.6.793

Evaluating the role of biomarkers for cardiovascular risk prediction: Focus on CRP, BNP and urinary microalbumin

Abigail May
, Thomas J. Wang

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Cardiovascular disease is a significant cause of morbidity and mortality, making cardiovascular prevention an important public health goal. The use of cardiac biomarkers represents a potential, noninvasive method to identify asymptomatic individuals who are most likely to develop cardiovascular disease. Several known biomarkers predict cardiovascular risk above and beyond conventional risk factors. Nonetheless, available evidence suggests that current biomarkers do not have sufficient sensitivity or specificity to justify widespread use for cardiovascular risk prediction. New developments in molecular biology and genetics may allow the identification of additional biomarkers, likely acting via different pathways, to achieve this goal.

Original language	English (US)
Pages (from-to)	793-804
Number of pages	12
Journal	Expert Review of Molecular Diagnostics
Volume	7
Issue number	6
DOIs	https://doi.org/10.1586/14737159.7.6.793
State	Published - Nov 2007
Externally published	Yes

Funding

This work was supported in part by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute (K23-HL-074077 and R01-HL-083197) and the American Heart Association. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
National Institute of Health National Heart, Lung, and Blood Institute	K23HL074077, R01-HL-083197
American Heart Association/American Stroke Association

Keywords

B-type natriuretic peptide
Biomarker
C-reactive protein
Cardiovascular risk
Urinary microalbumin

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Medicine
Molecular Biology
Genetics

Access to Document

10.1586/14737159.7.6.793

Cite this

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title = "Evaluating the role of biomarkers for cardiovascular risk prediction: Focus on CRP, BNP and urinary microalbumin",

abstract = "Cardiovascular disease is a significant cause of morbidity and mortality, making cardiovascular prevention an important public health goal. The use of cardiac biomarkers represents a potential, noninvasive method to identify asymptomatic individuals who are most likely to develop cardiovascular disease. Several known biomarkers predict cardiovascular risk above and beyond conventional risk factors. Nonetheless, available evidence suggests that current biomarkers do not have sufficient sensitivity or specificity to justify widespread use for cardiovascular risk prediction. New developments in molecular biology and genetics may allow the identification of additional biomarkers, likely acting via different pathways, to achieve this goal.",

keywords = "B-type natriuretic peptide, Biomarker, C-reactive protein, Cardiovascular risk, Urinary microalbumin",

author = "Abigail May and Wang, \{Thomas J.\}",

note = "Funding Information: This work was supported in part by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute (K23-HL-074077 and R01-HL-083197) and the American Heart Association. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2007",

month = nov,

doi = "10.1586/14737159.7.6.793",

language = "English (US)",

volume = "7",

pages = "793--804",

journal = "Expert Review of Molecular Diagnostics",

issn = "1473-7159",

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T1 - Evaluating the role of biomarkers for cardiovascular risk prediction

T2 - Focus on CRP, BNP and urinary microalbumin

AU - May, Abigail

AU - Wang, Thomas J.

N1 - Funding Information: This work was supported in part by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute (K23-HL-074077 and R01-HL-083197) and the American Heart Association. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2007/11

Y1 - 2007/11

N2 - Cardiovascular disease is a significant cause of morbidity and mortality, making cardiovascular prevention an important public health goal. The use of cardiac biomarkers represents a potential, noninvasive method to identify asymptomatic individuals who are most likely to develop cardiovascular disease. Several known biomarkers predict cardiovascular risk above and beyond conventional risk factors. Nonetheless, available evidence suggests that current biomarkers do not have sufficient sensitivity or specificity to justify widespread use for cardiovascular risk prediction. New developments in molecular biology and genetics may allow the identification of additional biomarkers, likely acting via different pathways, to achieve this goal.

AB - Cardiovascular disease is a significant cause of morbidity and mortality, making cardiovascular prevention an important public health goal. The use of cardiac biomarkers represents a potential, noninvasive method to identify asymptomatic individuals who are most likely to develop cardiovascular disease. Several known biomarkers predict cardiovascular risk above and beyond conventional risk factors. Nonetheless, available evidence suggests that current biomarkers do not have sufficient sensitivity or specificity to justify widespread use for cardiovascular risk prediction. New developments in molecular biology and genetics may allow the identification of additional biomarkers, likely acting via different pathways, to achieve this goal.

KW - B-type natriuretic peptide

KW - Biomarker

KW - C-reactive protein

KW - Cardiovascular risk

KW - Urinary microalbumin

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U2 - 10.1586/14737159.7.6.793

DO - 10.1586/14737159.7.6.793

M3 - Review article

C2 - 18020909

AN - SCOPUS:36448937142

SN - 1473-7159

VL - 7

SP - 793

EP - 804

JO - Expert Review of Molecular Diagnostics

JF - Expert Review of Molecular Diagnostics

IS - 6

ER -

Evaluating the role of biomarkers for cardiovascular risk prediction: Focus on CRP, BNP and urinary microalbumin

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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