Evaluation of Endoscopic Full-Thickness Plication on Anti-Reflux Valve Competency

James P. Dolan, Douglas M. Downey, Brett C. Sheppard, M. Brian Fennerty, John G. Hunter

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: We sought to investigate the efficacy of endoscopically created, full-thickness plications on the competency of the anti-reflux barrier when placed at different positions on the stomach adjacent to the gastroesophageal junction. Methods: Explanted human cadaver stomachs and esophagi were used. An endoscopic plication system (Plicator, NDO Surgical, Mansfield, Massachusetts) was then fitted over a pediatric gastroscope and passed through the esophagus into the stomach. A full-thickness plication implant was then deployed at 1 of 3 positions (fundus, anterior, and between the anterior and the lesser curvature) on the explanted stomach within 1 cm of the gastroesophageal junction. Intragastric pressure was measured before and after plication at the time of visible reflux from the esophagus (reflux threshold) using a water-perfused manometer. Results: Five explanted stomachs were used. The mean reflux threshold before plication (baseline) was 1.7 mm Hg. A single plication at each position resulted universally in a significantly increased reflux threshold over the baseline value (p < 0.006). The greatest reflux threshold was observed when plication was performed on the anterior wall of the stomach, although this reflux pressure did not achieve statistical significance over the other 2 positions. A second plication performed adjacent to the initial plication at the fundus (n = 2) and anterior (n = 2) positions did increase reflux threshold; however, this increase also failed to achieve statistical significance. Conclusions: These results suggest that an endoscopic, full-thickness plication system can inhibit gastroesophageal reflux effectively in an explanted stomach model. Although anterior plication resulted in the greatest intragastric pressure at reflux, it was not significantly different from intragastric pressure recorded at the other plication positions. A second plication adjacent to the first showed incremental effect, but larger studies are warranted to understand its clinical significance.

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalJournal of Surgical Education
Issue number2
StatePublished - Mar 2008


  • GERD
  • Medical Knowledge
  • Patient Care
  • Practice Based Learning and Improvement
  • Systems Based Practice
  • endoluminal therapy
  • endoscopy
  • plication

ASJC Scopus subject areas

  • Surgery
  • Education


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