Evaluation of salivary biomarker profiles following non-surgical management of chronic periodontitis

S. Prakasam, M. Srinivasan

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Objectives: Soluble toll-like receptor-2 (sTLR-2) and cytokines in saliva were assessed as clinical markers for chronic periodontitis in a longitudinal study. Materials and Methods: Unstimulated whole saliva was collected from 20 periodontally healthy individuals and 20 patients with chronic periodontitis at diagnosis and at 1 and 6 weeks following scaling and root planing (SRP). Biomarkers including the cytokines (IL-4, IL-6, IL-10, and IL-17), sTLR-2, and sCD14 in saliva were measured by enzyme-linked immunosorbent assay. Mann-Whitney U-test and Student's t-test were used to determine the significance between healthy and chronic periodontitis groups and that between pre- and post-SRP samples, respectively. Results: Salivary sTLR-2, IL-17, and IL-10 levels were significantly lower and those of sCD14, IL-6, and IL-4 were significantly higher in patients with chronic periodontitis as compared with healthy controls. Furthermore, sTLR-2 and IL-4 in saliva reached levels comparable to those of healthy individuals at 6-week re-evaluation visit, implicating a correlation of the two markers with the disease process. Conclusions: Our data suggest that salivary sTLR-2 is a potential prognostic or maintenance marker for chronic periodontitis. The observed variability of salivary cytokines is consistent with the role of these cytokines in the progression of chronic periodontitis.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalOral Diseases
Issue number2
StatePublished - Mar 2014
Externally publishedYes


  • Biological markers
  • CD14 antigen
  • Chronic periodontitis
  • Dental scaling
  • Diagnosis
  • Root planing
  • Saliva
  • Toll-like receptors

ASJC Scopus subject areas

  • Otorhinolaryngology
  • General Dentistry


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