Examining the immune response in sentinel lymph nodes of mice and men

Y. Chu, H. M. Hu, H. Winter, W. J. Wood, T. Doran, D. Lashley, J. Bashey, J. Schuster, J. Wood, B. A. Lowe, J. T. Vetto, A. D. Weinberg, R. Puri, J. W. Smith, W. J. Urba, B. A. Fox

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Recently, it was recognized that an immune response develops along one of two major pathways. One leads to a destructive immune response (type 1), while the alternative leads to a nondestructive immune response (type 2). Our studies in animal models suggest that therapeutic vaccines induce a tumor-specific type 1 immune response while ineffective vaccines induce a type 2 response. These results have led us to examine the immune response in sentinel lymph nodes draining tumor vaccines of patients entered onto clinical trials for melanoma, breast and renal cell cancer.

Original languageEnglish (US)
Pages (from-to)S50-S53
JournalEuropean Journal of Nuclear Medicine
Issue numberSUPPL.
StatePublished - 1999


  • Immune deviation
  • Immunological monitoring
  • Sentinel lymph nodes
  • Tumor vaccine-draining lymph nodes
  • Tumor vaccines

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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