Exhaled nitric oxide levels correlate with measures of disease control in asthma

Jeffrey M. Sippel, William E. Holden, Stephen A. Tilles, Mark O'Hollaren, Justin Cook, Nundhini Thukkani, James Priest, Bella Nelson, Molly L. Osborne

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


Background: Asthma guidelines emphasize maintaining disease control. However, objective measures of asthma disease control are lacking. Objective: We sought to examine the relationship between exhaled nitric oxide (NO) levels and measures of asthma disease control versus asthma disease severity. Methods: We performed a cross-sectional study of 100 patients (age range, 7-80 years) with asthma. We administered a questionnaire to identify characteristics of asthma, performed spirometric testing before and after administration of a bronchodilator, and measured exhaled NO levels in all participants. Results: Exhaled NO was significantly correlated with the following markers of asthma disease control: asthma symptoms within the past 2 weeks (P = .02), dyspnea score (P = .02), daily use of rescue medications (P = .01), and reversibility of airflow obstruction (P = .02). Exhaled NO levels were not correlated with the following markers of asthma disease severity: history of respiratory failure (P = .20), health care use (P = .08), fixed airflow obstruction (P = .91), or a validated asthma severity score (P = .19). Markers with relevance to both disease control and severity showed either a weak correlation (FEV1 and FEV1 percent predicted) or no correlation (controller drug use) with exhaled NO. Conclusion: We conclude that exhaled NO levels are correlated predominantly with markers of asthma control rather than asthma severity. Monitoring of exhaled NO may be useful in outpatient asthma management.

Original languageEnglish (US)
Pages (from-to)645-650
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Issue number4
StatePublished - 2000
Externally publishedYes


  • Asthma
  • Disease control
  • Epidemiology
  • Exhaled nitric oxide
  • Nitric oxide

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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