Exocytosis unbound

Ko Matsui; Craig E. Jahr

doi:10.1016/j.conb.2006.04.001

Exocytosis unbound

Ko Matsui
, Craig E. Jahr

Vollum Institute

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential, and there is growing evidence that neuronal exocytosis can occur from sites that are unremarkable in electron micrographs. The first discrepancy extends the dynamic range of synapses, whereas the second enables faster and more robust chemical transmission at sites distant from morphologically defined synapses. Taken together, these attributes expand the capabilities of cellular communication in the nervous system.

Original language	English (US)
Pages (from-to)	305-311
Number of pages	7
Journal	Current Opinion in Neurobiology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.conb.2006.04.001
State	Published - Jun 2006

Funding

We thank members of the Jahr laboratory for their input and advice. Supported by National Institutes of Health grant NS40056.

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
National Institute of Neurological Disorders and Stroke	R01NS040056

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.conb.2006.04.001

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title = "Exocytosis unbound",

abstract = "The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential, and there is growing evidence that neuronal exocytosis can occur from sites that are unremarkable in electron micrographs. The first discrepancy extends the dynamic range of synapses, whereas the second enables faster and more robust chemical transmission at sites distant from morphologically defined synapses. Taken together, these attributes expand the capabilities of cellular communication in the nervous system.",

author = "Ko Matsui and Jahr, \{Craig E.\}",

note = "Funding Information: We thank members of the Jahr laboratory for their input and advice. Supported by National Institutes of Health grant NS40056. ",

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AB - The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential, and there is growing evidence that neuronal exocytosis can occur from sites that are unremarkable in electron micrographs. The first discrepancy extends the dynamic range of synapses, whereas the second enables faster and more robust chemical transmission at sites distant from morphologically defined synapses. Taken together, these attributes expand the capabilities of cellular communication in the nervous system.

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VL - 16

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ER -

Exocytosis unbound

Abstract

Funding

ASJC Scopus subject areas

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