Abstract
The encephalitogenic difference between purified guinea pig and bovine myelin proteins in the Lewis rat is reflected by the two molecules' lack of crossreactivity in the migration inhibition test. Peritoneal exudate cells from rats injected with guinea pig or bovine derived myelin basic protein in Freund's complete adjuvant demonstrate substantial migration inhibition to the sensitizing antigen but little inhibition when cultured in the presence of the other basic protein. The cellular reactivity to guinea pig basic protein is present throughout the induction phase of Experimental Allergic Encephalomyelitis and persists after the recovery of the rats from the paralytic state. Substantial cellular reactivity is also demonstrated to bovine basic protein even though this molecule shows minimal encephalitogenic activity in the Lewis rat. Minimal lymphocyte transformation could be demonstrated to either of the basic proteins, although the immune cells react strongly to the plant mitogen phytohemagglutinin and to a Mycobacterium tuberculosis antigen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-93 |
| Number of pages | 9 |
| Journal | Cellular Immunology |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1974 |
| Externally published | Yes |
Funding
We thank Mr. Bruce Gibbins and Mr. Howard Raff for their assistance research and Mrs. S. Holcomb for typing the manuscript. This investigation was supported in part by funds provided research by the State of Washington Initiative Measure No. 171.
| Funders | Funder number |
|---|---|
| State of Washington Initiative Measure | 171 |
ASJC Scopus subject areas
- Immunology
Fingerprint
Dive into the research topics of 'Experimental Allergic Encephalomyelitis and cellular immunity in the Lewis rat'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS