Expression of the c-myc Protooncogene in Human Prostatic Carcinoma and Benign Prostatic Hyperplasia

William H. Fleming, Andre Hamel, Janice G. Dodd, Robert J. Matusik, Robert MacDonald, Ernest Ramsey, Norman M. Pettiarew, Brian Johnston

Research output: Contribution to journalArticlepeer-review

176 Scopus citations

Abstract

We have examined the level of c-myc transcripts in prostate tissue obtained from patients with both benign prostatic hyperplasia and adenocarcinoma of the prostate. A significantly higher level of c-myc transcripts is observed in patients with adenocarcinoma (P < 0.05). In addition, a subset of patients with adenocarcinoma had levels of c-myc transcripts 2-fold higher than the mean level for this group. These preliminary results indicate that the investigation of c-myc levels as a prognostic indicator in prostatic carcinoma is warranted.

Original languageEnglish (US)
Pages (from-to)1535-1538
Number of pages4
JournalCancer Research
Volume46
Issue number3
StatePublished - Mar 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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