@article{2ecc118a19d04978b461e0c7c9387777,
title = "Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma",
abstract = "The development of targeted therapeutics for neuroblastoma, the third most common tumor in children, has been limited by a poor understanding of growth signaling mechanisms unique to the peripheral nerve precursors from which tumors arise. In this study, we combined genetics with gene-expression analysis in the peripheral sympathetic nervous system to implicate arginase 1 and GABA signaling in tumor formation in vivo. In human neuroblastoma cells, either blockade of ARG1 or benzodiazepinemediated activation of GABA-A receptors induced apoptosis and inhibited mitogenic signaling through AKT and MAPK. These results suggest that ARG1 and GABA influence both neural development and neuroblastoma and that benzodiazepines in clinical use may have potential applications for neuroblastoma therapy.",
author = "Hackett, {Christopher S.} and Quigley, {David A.} and Wong, {Robyn A.} and Justin Chen and Christine Cheng and Song, {Young K.} and Wei, {Jun S.} and Ludmila Pawlikowska and Yun Bao and Goldenberg, {David D.} and Kim Nguyen and {Clay Gustafson}, W. and Rallapalli, {Sundari K.} and Cho, {Yoon Jae} and Cook, {James M.} and Serguei Kozlov and Mao, {Jian Hua} and {Van Dyke}, Terry and Kwok, {Pui Yan} and Javed Khan and Allan Balmain and Fan, {Qi Wen} and Weiss, {William A.}",
note = "Funding Information: The authors are grateful to the Marshfield Clinic and CIDR for genotyping, and to Fernando Pardo Manuel de Villena, Gary Churchill, Saunak Sen, Denise Lind, and Roger Nicoll for experimental advice and comments on the manuscript. This work was supported by the March of Dimes; the Concern Foundation; the UCSF Academic Senate; NIH R01CA102321, R01NS055750, P30CA82103, U01CA176287, and an ARRA supplement for R01NS055750 (to W.A.W.); and NIH R01MH046851, MH096463, and NS076517 (to J.M.C.). Publisher Copyright: {\textcopyright} 2014 The Authors.",
year = "2014",
doi = "10.1016/j.celrep.2014.09.046",
language = "English (US)",
volume = "9",
pages = "1034--1046",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}