TY - JOUR
T1 - Extrinsic regulators of epithelial tumor progression
T2 - Metalloproteinases
AU - Bergers, Gabriele
AU - Coussens, Lisa M.
N1 - Funding Information:
We acknowledge all the scientists who made contributions to the areas of research reviewed here that we could not cite due to space constraints. We also thank Douglas Hanahan and Zena Werb for critical comments. This work was supported in part by funds from the National Institutes of Health and the American Cancer Society.
PY - 2000/2/1
Y1 - 2000/2/1
N2 - Extracellular metal-dependent proteinases regulate cell behavior by remodeling stromal and cell surface proteins, thereby influencing cell recruitment, cell shape, motility, proliferation, survival, genomic (in)stability, and differentiation. In recent years, the importance of proteinase-induced signaling has been underscored by evidence that altered regulation of cell-extracellular matrix and cell-cell interactions by proteinases can contribute, in a causal manner, to neoplastic progression.
AB - Extracellular metal-dependent proteinases regulate cell behavior by remodeling stromal and cell surface proteins, thereby influencing cell recruitment, cell shape, motility, proliferation, survival, genomic (in)stability, and differentiation. In recent years, the importance of proteinase-induced signaling has been underscored by evidence that altered regulation of cell-extracellular matrix and cell-cell interactions by proteinases can contribute, in a causal manner, to neoplastic progression.
UR - http://www.scopus.com/inward/record.url?scp=0033994361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033994361&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(99)00043-X
DO - 10.1016/S0959-437X(99)00043-X
M3 - Review article
C2 - 10679388
AN - SCOPUS:0033994361
SN - 0959-437X
VL - 10
SP - 120
EP - 127
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 1
ER -