Extrinsic regulators of epithelial tumor progression: Metalloproteinases

Gabriele Bergers, Lisa M. Coussens

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Extracellular metal-dependent proteinases regulate cell behavior by remodeling stromal and cell surface proteins, thereby influencing cell recruitment, cell shape, motility, proliferation, survival, genomic (in)stability, and differentiation. In recent years, the importance of proteinase-induced signaling has been underscored by evidence that altered regulation of cell-extracellular matrix and cell-cell interactions by proteinases can contribute, in a causal manner, to neoplastic progression.

Original languageEnglish (US)
Pages (from-to)120-127
Number of pages8
JournalCurrent Opinion in Genetics and Development
Issue number1
StatePublished - Feb 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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