Eye-of-the-Tiger Sign

Research output: Chapter in Book/Report/Conference proceedingChapter


The eye-of-the-tiger sign describes the magnetic resonance imaging (MRI) changes seen in pantothenate kinase-associated neurodegeneration (PKAN) on T2-weighted study. The specific changes are hypointense signal in globus pallidus with a region of central or anteromedial hyperintensity. This sign is virtually pathognomic for PKAN. The hypointense region represents high tissue iron and the hyperintense region edema.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Number of pages2
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
StatePublished - Jan 1 2010


  • Basal ganglia
  • Globus pallidus
  • Hallervorden-Spatz syndrome
  • PANK2
  • Pantothenate kinase-associated neurodegeneration
  • T-weighted MRI

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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