Eye-of-the-Tiger Sign

S. J. Hayflick

doi:10.1016/B978-0-12-374105-9.00122-2

Eye-of-the-Tiger Sign

S. J. Hayflick

Molecular and Medical Genetics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The eye-of-the-tiger sign describes the magnetic resonance imaging (MRI) changes seen in pantothenate kinase-associated neurodegeneration (PKAN) on T₂-weighted study. The specific changes are hypointense signal in globus pallidus with a region of central or anteromedial hyperintensity. This sign is virtually pathognomic for PKAN. The hypointense region represents high tissue iron and the hyperintense region edema.

Original language	English (US)
Title of host publication	Encyclopedia of Movement Disorders, Three-Volume Set
Publisher	Elsevier
Pages	V1-471-V1-472
ISBN (Electronic)	9780123741059
DOIs	https://doi.org/10.1016/B978-0-12-374105-9.00122-2
State	Published - Jan 1 2010

Keywords

Basal ganglia
Globus pallidus
Hallervorden-Spatz syndrome
PANK2
Pantothenate kinase-associated neurodegeneration
T-weighted MRI

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1016/B978-0-12-374105-9.00122-2

Cite this

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title = "Eye-of-the-Tiger Sign",

abstract = "The eye-of-the-tiger sign describes the magnetic resonance imaging (MRI) changes seen in pantothenate kinase-associated neurodegeneration (PKAN) on T2-weighted study. The specific changes are hypointense signal in globus pallidus with a region of central or anteromedial hyperintensity. This sign is virtually pathognomic for PKAN. The hypointense region represents high tissue iron and the hyperintense region edema.",

keywords = "Basal ganglia, Globus pallidus, Hallervorden-Spatz syndrome, PANK2, Pantothenate kinase-associated neurodegeneration, T-weighted MRI",

author = "Hayflick, \{S. J.\}",

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doi = "10.1016/B978-0-12-374105-9.00122-2",

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AB - The eye-of-the-tiger sign describes the magnetic resonance imaging (MRI) changes seen in pantothenate kinase-associated neurodegeneration (PKAN) on T2-weighted study. The specific changes are hypointense signal in globus pallidus with a region of central or anteromedial hyperintensity. This sign is virtually pathognomic for PKAN. The hypointense region represents high tissue iron and the hyperintense region edema.

KW - Basal ganglia

KW - Globus pallidus

KW - Hallervorden-Spatz syndrome

KW - PANK2

KW - Pantothenate kinase-associated neurodegeneration

KW - T-weighted MRI

UR - https://www.scopus.com/pages/publications/85184554199

UR - https://www.scopus.com/pages/publications/85184554199#tab=citedBy

U2 - 10.1016/B978-0-12-374105-9.00122-2

DO - 10.1016/B978-0-12-374105-9.00122-2

M3 - Chapter

AN - SCOPUS:85184554199

SP - V1-471-V1-472

BT - Encyclopedia of Movement Disorders, Three-Volume Set

PB - Elsevier

ER -

Eye-of-the-Tiger Sign

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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