@article{575025a493ea4a58b28ad863a3114975,
title = "Failure of breast cancer cells in long-term culture to aromatize androstenedione",
abstract = "The ability of breast cancer cells in long-term tissue culture to aromatize androstenedione to estrone and estradiol was examined. (3H) androstenedione (1.1 × 10-7M) was incubated with 9 cell lines of human breast cancer and one line derived froa a dimethylbenz(a)anthracene induced rat mammary tumor. No conversion to estrone or estradiol was detected. The findings are discussed in light of previous studies showing aromatization of androgens in breast cancer tissues.",
author = "R. D'Agata and Monaco, {M. E.} and Lippman, {M. E.} and Loriaux, {D. L.}",
note = "Funding Information: Medicine Branch, National Cancer Institute and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20014 Funding Information: 1,2,6,7-3B androstenedione (104 Ci/mmol), 6,7-3H estradiol glucuronide (42 Ci/mpnol) and 6,7-3H estron sulfate (48 Ci/nnnol) were urchased from New England Nuclear Corp. f4C estradiol (56 mCi/mmol), C estr ne (55 mCi/nnnol), 2,4,6,7-3B estradiol (115 Ci/raaol) and p4 2,4,6,7-s Ii estrone (89 Ci/mmol) were purchased from AmershamS earle. All other nonradioactive steroids were obtained from Steraloids Inc. A variety of humanb reast cell lines and one rat cell line were used. MCF-7 1223 was generously provided by Marvin Rich of the Michigan Cancer Foundation. ZR-75-1, ZR-75-27 and ZR-75-30 were established by Nathaniel Young and Linda Engel of the National Cancer Institute, MDA-231 1231, BT-20, HT-39, G-11 were supplied by Ronald Herbermsn (NIH, Bethesda). EVSA-T was established In our own laboratory 1241 and WRR-1 was derived from a dimethylbens(a)anthracene induced rat mammarytu mor [25]. Recent data have suggested that HT-39 and G-11 may be HeLa but the human and mammarny ature of the other cell lines employed is established.",
year = "1978",
month = apr,
doi = "10.1016/0039-128X(78)90028-4",
language = "English (US)",
volume = "31",
pages = "463--470",
journal = "Steroids",
issn = "0039-128X",
publisher = "Elsevier Inc.",
number = "4",
}