To the Editor: In the July 26 issue, Nadi et al.1 reported that primary cultures of human skin fibroblasts “possess muscarinic receptors with the properties of specific binding, saturability, pharmacologic specificity, inhibition of norepinephrine-stimulated adenylate cyclase, and increased binding after incubation with an antagonist.” The authors also indicated that the fibroblasts of patients with a major affective disorder (or a relative with a history of a major or minor depressive disorder) had a significantly higher density of muscarinic binding sites as determined by the binding of the radioactive antagonist ligand [3H]quinuclidinyl benzilate ([3H]QNB) than did control subjects. They.
|Original language||English (US)|
|Number of pages||2|
|Journal||New England Journal of Medicine|
|State||Published - Mar 28 1985|
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