Fast adaptation in vestibular hair cells requires Myosin-1c activity

Eric A. Stauffer, John D. Scarborough, Moritoshi Hirono, Emilie D. Miller, Kavita Shah, John A. Mercer, Jeffrey R. Holt, Peter G. Gillespie

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


In sensory hair cells of the inner ear, mechanical amplification of small stimuli requires fast adaptation, the rapid closing of mechanically activated transduction channels. In frog and mouse vestibular hair cells, we found that the rate of fast adaptation depends on both channel opening and stimulus size and that it is modeled well as a release of a mechanical element in series with the transduction apparatus. To determine whether myosin-1c molecules of the adaptation motor are responsible for the release, we introduced the Y61G mutation into the Myo1c locus and generated mice homozygous for this sensitized allele. Measuring transduction and adaptation in the presence of NMB-ADP, an allele-specific inhibitor, we found that the inhibitor not only blocked slow adaptation, as demonstrated previously in transgenic mice, but also inhibited fast adaptation. These results suggest that mechanical activity of myosin-1c is required for fast adaptation in vestibular hair cells.

Original languageEnglish (US)
Pages (from-to)541-553
Number of pages13
Issue number4
StatePublished - Aug 18 2005

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Fast adaptation in vestibular hair cells requires Myosin-1c activity'. Together they form a unique fingerprint.

Cite this