Fcγ receptor effects on induction of c-myc mRNA expression in mouse B lymphocytes by anti-immunoglobulin

Nancy E. Phillips; David C. Parker

doi:10.1016/0161-5890(87)90166-0

Fcγ receptor effects on induction of c-myc mRNA expression in mouse B lymphocytes by anti-immunoglobulin

Nancy E. Phillips
, David C. Parker

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Levels of c-myc mRNA have been assayed in mouse B cells cultured for 8 hr with Fab'₂ anti-Ig or IgG anti-Ig. Fab'₂ anti-Ig induces DNA synthesis in B cells, whereas the whole molecule inhibits anti-Ig-induced DNA synthesis by crosslinking the B cell Fcγ R to mIg. Both the Fab'₂ fragment and the IgG anti-Ig induce an increase in c-myc mRNA by 1 hr. Thereafter, levels in cells stimulated with submitogenic doses of Fab'₂ anti-Ig or any dose of IgG anti-Ig returned to background, while levels in cultures containing a mitogenic dose of Fab'₂ anti-Ig remained elevated.

Original language	English (US)
Pages (from-to)	1199-1205
Number of pages	7
Journal	Molecular Immunology
Volume	24
Issue number	11
DOIs	https://doi.org/10.1016/0161-5890(87)90166-0
State	Published - Nov 1987
Externally published	Yes

Funding

*This work was supported by Research Grant IM-327 from the American Cancer Society and Biomedical Research Support Grant S07RR5712 from the National Insti-tutes of Health. N.E. Phillips is supported by an Arthritis Foundation Investigator Award. tAuthor to whom correspondence should be addressed. $Abbreviations: Con A, Concanavalin A; Fey R, receptor for IgG Fc; LPS, lipopolysaccharide; MAb, monoclonal antibody; mIa, membrane immune response-associated antigens; mIg, membrane immunoglobulin.

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
American Cancer Society-Stanford Cancer Institute	S07RR5712
National Center for Research Resources	S07RR005712
Arthritis Foundation

ASJC Scopus subject areas

Immunology
Molecular Biology

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10.1016/0161-5890(87)90166-0

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title = "Fcγ receptor effects on induction of c-myc mRNA expression in mouse B lymphocytes by anti-immunoglobulin",

abstract = "Levels of c-myc mRNA have been assayed in mouse B cells cultured for 8 hr with Fab'2 anti-Ig or IgG anti-Ig. Fab'2 anti-Ig induces DNA synthesis in B cells, whereas the whole molecule inhibits anti-Ig-induced DNA synthesis by crosslinking the B cell Fcγ R to mIg. Both the Fab'2 fragment and the IgG anti-Ig induce an increase in c-myc mRNA by 1 hr. Thereafter, levels in cells stimulated with submitogenic doses of Fab'2 anti-Ig or any dose of IgG anti-Ig returned to background, while levels in cultures containing a mitogenic dose of Fab'2 anti-Ig remained elevated.",

author = "Phillips, \{Nancy E.\} and Parker, \{David C.\}",

note = "Funding Information: *This work was supported by Research Grant IM-327 from the American Cancer Society and Biomedical Research Support Grant S07RR5712 from the National Insti-tutes of Health. N.E. Phillips is supported by an Arthritis Foundation Investigator Award. tAuthor to whom correspondence should be addressed. \$Abbreviations: Con A, Concanavalin A; Fey R, receptor for IgG Fc; LPS, lipopolysaccharide; MAb, monoclonal antibody; mIa, membrane immune response-associated antigens; mIg, membrane immunoglobulin.",

year = "1987",

month = nov,

doi = "10.1016/0161-5890(87)90166-0",

language = "English (US)",

volume = "24",

pages = "1199--1205",

journal = "Molecular Immunology",

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T1 - Fcγ receptor effects on induction of c-myc mRNA expression in mouse B lymphocytes by anti-immunoglobulin

AU - Phillips, Nancy E.

AU - Parker, David C.

N1 - Funding Information: *This work was supported by Research Grant IM-327 from the American Cancer Society and Biomedical Research Support Grant S07RR5712 from the National Insti-tutes of Health. N.E. Phillips is supported by an Arthritis Foundation Investigator Award. tAuthor to whom correspondence should be addressed. $Abbreviations: Con A, Concanavalin A; Fey R, receptor for IgG Fc; LPS, lipopolysaccharide; MAb, monoclonal antibody; mIa, membrane immune response-associated antigens; mIg, membrane immunoglobulin.

PY - 1987/11

Y1 - 1987/11

N2 - Levels of c-myc mRNA have been assayed in mouse B cells cultured for 8 hr with Fab'2 anti-Ig or IgG anti-Ig. Fab'2 anti-Ig induces DNA synthesis in B cells, whereas the whole molecule inhibits anti-Ig-induced DNA synthesis by crosslinking the B cell Fcγ R to mIg. Both the Fab'2 fragment and the IgG anti-Ig induce an increase in c-myc mRNA by 1 hr. Thereafter, levels in cells stimulated with submitogenic doses of Fab'2 anti-Ig or any dose of IgG anti-Ig returned to background, while levels in cultures containing a mitogenic dose of Fab'2 anti-Ig remained elevated.

AB - Levels of c-myc mRNA have been assayed in mouse B cells cultured for 8 hr with Fab'2 anti-Ig or IgG anti-Ig. Fab'2 anti-Ig induces DNA synthesis in B cells, whereas the whole molecule inhibits anti-Ig-induced DNA synthesis by crosslinking the B cell Fcγ R to mIg. Both the Fab'2 fragment and the IgG anti-Ig induce an increase in c-myc mRNA by 1 hr. Thereafter, levels in cells stimulated with submitogenic doses of Fab'2 anti-Ig or any dose of IgG anti-Ig returned to background, while levels in cultures containing a mitogenic dose of Fab'2 anti-Ig remained elevated.

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SN - 0161-5890

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Fcγ receptor effects on induction of c-myc mRNA expression in mouse B lymphocytes by anti-immunoglobulin

Abstract

Funding

ASJC Scopus subject areas

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