TY - JOUR
T1 - Feline uveal melanomas induced with feline sarcoma virus
T2 - Potential model of the human counterpart
AU - Shadduck, John A.
AU - Albert, Daniel M.
AU - Niederkorn, Jerry Y.
N1 - Funding Information:
1 Received June 24, 1980; revised February 13, 1981; accepted March 9, 1981. 2 Supported by Public Health Service grant EY02678 from the National Eye Institute and by a grant from Southwestern Medical Foundation. 3 Animals were maintained under the guidelines of the Texas Health Science Center at Dallas. 4 Division of Comparative Medicine, Department of Pathology, Southwestern Medical School, Dallas, Tex. 75235. , Address reprint requests to Dr. Shadduck at his present address: Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Ill. 6180l. 6 Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Mass. 02114. 7 Department of Ophthalmology, Southwestern Medical School, Dallas, Tex. 75235. 8 The excellent technical assistance of Mary Jean Geroulo, Ronald Hervey, Sally Lause, George Lawton, Nancy Robinson, and Joseph Craft is acknowledged.
PY - 1981/9
Y1 - 1981/9
N2 - Uveal melanomas were produced by injecting Gardner strain feline fibrosarcoma virus intraocularly into 10- to 15- day-old noninbred kittens. Tumors developed in about 90% of the cats' eyes receiving virus. Progressing tumors (62 eyes of 36 cats) began as small hyperpigmented lesions at the site of injection and grew to fill the anterior chamber by 3–5 months after infection. About 30% of cats with these tumors developed secondary tumors and died. Nonprogressive tumors characterized by flat, pigmented plaques on the iris at the site of injection developed in 25 eyes of 18 cats. These lesions did not enlarge except in proportion to the growth of the eye. Tumors were composed of pigmented spindle cells, pigmented epithelioid cells, and nonpigmented spindle cells. The cells could be grown for 5–8 passages in vitro. One culture assumed a transformed morphology and grew in noninbred athymic nu/numice. The lesions resembled human spindle cell melanomas.
AB - Uveal melanomas were produced by injecting Gardner strain feline fibrosarcoma virus intraocularly into 10- to 15- day-old noninbred kittens. Tumors developed in about 90% of the cats' eyes receiving virus. Progressing tumors (62 eyes of 36 cats) began as small hyperpigmented lesions at the site of injection and grew to fill the anterior chamber by 3–5 months after infection. About 30% of cats with these tumors developed secondary tumors and died. Nonprogressive tumors characterized by flat, pigmented plaques on the iris at the site of injection developed in 25 eyes of 18 cats. These lesions did not enlarge except in proportion to the growth of the eye. Tumors were composed of pigmented spindle cells, pigmented epithelioid cells, and nonpigmented spindle cells. The cells could be grown for 5–8 passages in vitro. One culture assumed a transformed morphology and grew in noninbred athymic nu/numice. The lesions resembled human spindle cell melanomas.
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U2 - 10.1093/jnci/67.3.619
DO - 10.1093/jnci/67.3.619
M3 - Article
C2 - 6268880
AN - SCOPUS:0019512072
SN - 0027-8874
VL - 67
SP - 619
EP - 627
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 3
ER -