Fibrillin delineates the primary axis of the early avian embryo

Betty C. Gallagher, Lynn Y. Sakai, Charles D. Little

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Chicken embryos were immunolabeled with antibodies to fibrillin, an extracelular matrix molecule implicated in the Marfan syndrome. The pattern of labeling, established using both whole‐mounted and sectioned embryos, showed a striking localization at the primary axis of the early embryo, including Hensen's node. After stage 8, the labeling of Hensen's node diminished while other structures in the embryo exhibited increased immunolabeling. These structures include the region of the presumptive dorsal aorta, the ventral surface of the notochord, and the mesocardium. Injections of the antibody between the vitelline membrane and the blastoderm in vivo failed to perturb the development of embryos, thus precluding any conclusions regarding the function of fibrillin. © 1993 wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)70-78
Number of pages9
JournalDevelopmental Dynamics
Issue number1
StatePublished - Jan 1993


  • Avian embryos
  • Dorsal mesoderm
  • Fibrillin
  • Hensen's node
  • Marfan syndrome
  • Primary axis
  • Primitive streak

ASJC Scopus subject areas

  • Developmental Biology


Dive into the research topics of 'Fibrillin delineates the primary axis of the early avian embryo'. Together they form a unique fingerprint.

Cite this