@inproceedings{dd263822583a48dab8ff4d5a8392f0f5,
title = "Fine-tuning physicochemical properties of Oxazine-4 for nerve-specific imaging",
abstract = "Accidental damage of vital nerve structures remains a significant surgical morbidity. Patient-to-patient neuroanatomical variability requires considerable dependence on a surgeon's first-hand experiences that primarily rely on proximal features for orientation, which can be further complicated in patients with nerve damage. As such, enhanced nerve visualization proves to be a vital avenue for advancing surgical precision and patient outcomes. Fluorescence guided surgery (FGS) has the potential to improve surgical guidance, but there are no current nerve-specific fluorophores approved for clinical use. Previous work has identified the oxazine scaffold as a promising avenue for nerve-specific contrast agent development, due to its sufficiently low molecular weight to cross the blood-nerve-barrier (BNB), tunable photophysical properties, and high nerve specificity. Herein we report our efforts to investigate the structure-function relationship of Oxazine-4 through fine-tuned terminal alkylamino modifications, both based on optical and physicochemical properties as well as their affected nerve specificities.",
keywords = "Contrast agent, Fluorescence imaging, Fluorescence-guided surgery, Nerve-specific fluorophores",
author = "Greer, {William S.} and Antonio Monta{\~n}o and Shams, {Nourhan A.} and Dani Szafran-Reeder and Anas Masillati and Wang, {Lei G.} and Gibbs, {Summer L.}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE.; Molecular-Guided Surgery: Molecules, Devices, and Applications VIII 2022 ; Conference date: 20-02-2022 Through 24-02-2022",
year = "2022",
doi = "10.1117/12.2612232",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Sylvain Gioux and Gibbs, {Summer L.} and Pogue, {Brian W.}",
booktitle = "Molecular-Guided Surgery",
}