Abstract
Purpose: To test the effectiveness (Participant A) and tolerability (Participant B) of urinary stone comminution in the first-in-human trial of a new technology, burst-wave lithotripsy (BWL). Materials and Methods: An investigational BWL and ultrasonic propulsion system was used to target a 7-mm kidney stone in the operating room before ureteroscopy (Participant A). The same system was used to target a 7.5 mm ureterovesical junction stone in clinic without anesthesia (Participant B). Results: For Participant A, a ureteroscope inserted after 9 minutes of BWL observed fragmentation of the stone to <2 mm fragments. Participant B tolerated the procedure without pain from BWL, required no anesthesia, and passed the stone on day 15. Conclusions: The first-in-human tests of BWL pulses were successful in that a renal stone was comminuted in <10 minutes, and BWL was also tolerated by an awake subject for a distal ureteral stone. Clinical Trial NCT03873259 and NCT02028559.
Original language | English (US) |
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Pages (from-to) | 506-511 |
Number of pages | 6 |
Journal | Journal of Endourology |
Volume | 35 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2021 |
Externally published | Yes |
Keywords
- Burst wave lithotripsy
- Calculi
- Lithotripsy
- Physics
- Shock wave lithotripsy
- Ultrasound
- Urolithiasis
ASJC Scopus subject areas
- Urology