Fish oils in hypertriglyceridemia: A dose-response study

William S. Harris, Douglas W. Rothrock, Ann Fanning, Stephen B. Inkeles, Scott H. Goodnight, D. Roger Illingworth, William E. Connor

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


The effects of three supplemental doses of fish oil on plasma lipids, lipoproteins, and bleeding times were studied in ten hypertriglyceridemic patients. After a 3-wk base-line period each patient was given 15, 25, or 40 mL fish oil/d (containing 4.5, 7.5, and 12 g n-3 fatty acids) for three successive 6-wk periods, each separated by a 4-wk period of no supplementation. Plasma cholesterol concentrations decreased from 7.40 mmol/L to 6.35, 6.55, and 6.40 mmol/L with increasing doses of fish oil (p < 0.01 vs baseline for each). Plasma triglyceride concentrations decreased from 6.10 mmol/L to 2.90, 2.80, and 2.35 mmol/L (p < 0.01 vs baseline for each). Low-density-lipoprotein cholesterol concentrations increased significantly (by 23% and 28%) with the two higher doses, respectively. Bleeding times increased only with the largest dose. The lowest dose was the most hypolipidemic per gram n-3 fatty acids.

Original languageEnglish (US)
Pages (from-to)399-406
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Issue number3
StatePublished - Mar 1990
Externally publishedYes


  • Dietary fats
  • Fish oils
  • Hypercholesterolemia
  • Hypertriglyceridemia
  • Lipoproteins
  • Plasma lipids
  • Platelets
  • Unsaturated fatty acids

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Medicine (miscellaneous)


Dive into the research topics of 'Fish oils in hypertriglyceridemia: A dose-response study'. Together they form a unique fingerprint.

Cite this