Fishing for a balance: Toward promyelinating drug discovery

Hannah Y. Collins; Ben Emery

doi:10.1016/j.chembiol.2022.09.005

Fishing for a balance: Toward promyelinating drug discovery

Hannah Y. Collins
, Ben Emery

Neurology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In this issue, Häberlein et al. demonstrate a role for GPR17 in regulating zebrafish oligodendrocyte differentiation. Zebrafish expressing a humanized GPR17 respond to modulators, which are inactive against the endogenous zebrafish receptor. These findings highlight the potential for humanized zebrafish as an in vivo platform for targeted remyelination drug screens.

Original language	English (US)
Pages (from-to)	1467-1469
Number of pages	3
Journal	Cell Chemical Biology
Volume	29
Issue number	10
DOIs	https://doi.org/10.1016/j.chembiol.2022.09.005
State	Published - Oct 20 2022

Funding

This work is supported, in part, by the National Institutes of Health (grant number R01-NS120981 ). BE is supported by an endowment from the Warren family. H.Y.C. is supported by National Institutes of Health NRSA NS122433 .

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	NS122433
National Institute of Neurological Disorders and Stroke	R01NS120981

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2022.09.005

Cite this

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abstract = "In this issue, H{\"a}berlein et al. demonstrate a role for GPR17 in regulating zebrafish oligodendrocyte differentiation. Zebrafish expressing a humanized GPR17 respond to modulators, which are inactive against the endogenous zebrafish receptor. These findings highlight the potential for humanized zebrafish as an in vivo platform for targeted remyelination drug screens.",

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AU - Emery, Ben

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AB - In this issue, Häberlein et al. demonstrate a role for GPR17 in regulating zebrafish oligodendrocyte differentiation. Zebrafish expressing a humanized GPR17 respond to modulators, which are inactive against the endogenous zebrafish receptor. These findings highlight the potential for humanized zebrafish as an in vivo platform for targeted remyelination drug screens.

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M3 - Comment/debate

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AN - SCOPUS:85139838358

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JO - Cell Chemical Biology

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Fishing for a balance: Toward promyelinating drug discovery

Abstract

Funding

ASJC Scopus subject areas

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