Fishing for key players in mechanotransduction

Teresa Nicolson

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


The senses of touch and hearing involve transduction of mechanical stimuli into electrical signals. The search for components of the transduction apparatus in mechanosensory neurons has benefited greatly from genetic approaches using both invertebrates and vertebrates. A consensus model has emerged that includes extracellular and intracellular structural components arranged around a central mechanically gated channel. In the sensory hair cell of the inner ear, the extracellular structural component thought to have a key role in opening the transduction channel is the tip link. Although elusive for decades, recent studies have yielded candidates for both the transduction channel and the tip link in hair cells.

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalTrends in Neurosciences
Issue number3
StatePublished - Mar 2005
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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