TY - JOUR
T1 - Folate intake and prostate cancer risk
T2 - A case-control study
AU - Shannon, Jackilen
AU - Phoutrides, Elena
AU - Palma, Amy
AU - Farris, Paige
AU - Peters, Laura
AU - Forester, Anna
AU - Tillotson, Carrie J.
AU - Garzotto, Mark
N1 - Funding Information:
This study was supported by United States Public Health Service grants 5 M01 RR000334, 1 UL1 RR024120–01, and K22CA94973 and the resources and facilities of the Portland Veterans Affairs Medical Center. VA Advanced Career Development Award (M. Garzotto) Biostatistics support was provided through the OHSU Cancer Institute Biostatistics Shared Resource (P30 CA069533-09) and the Oregon Clinical and Translational Research Institute (UL1 RR024140).
PY - 2009/9
Y1 - 2009/9
N2 - Folate deficiency has been implicated in the carcinogenesis of several tumor types. The role of folate in prostate cancer remains indeterminate. We investigated folate as a risk factor for prostate cancer among 140 biopsy-confirmed prostate cancer patients, 230 age-matched clinic controls, and 250 negative prostate biopsy controls. Dietary folate intake was inversely associated with overall risk of prostate cancer as compared to clinic controls (P for a linear trend = 0.003). When stratified by disease severity, dietary folate and folate from natural sources were associated with reduced risk of high-grade cancer as compared to both clinic controls (P for a linear trend = 0.0009 and 0.02, respectively) and biopsy negative controls (P for a linear trend = 0.03 and 0.05, respectively). There was no interaction between alcohol consumption and folate intake. These analyses support an inverse association between dietary folate intake and prostate cancer risk and primarily risk of high-grade prostate cancer.
AB - Folate deficiency has been implicated in the carcinogenesis of several tumor types. The role of folate in prostate cancer remains indeterminate. We investigated folate as a risk factor for prostate cancer among 140 biopsy-confirmed prostate cancer patients, 230 age-matched clinic controls, and 250 negative prostate biopsy controls. Dietary folate intake was inversely associated with overall risk of prostate cancer as compared to clinic controls (P for a linear trend = 0.003). When stratified by disease severity, dietary folate and folate from natural sources were associated with reduced risk of high-grade cancer as compared to both clinic controls (P for a linear trend = 0.0009 and 0.02, respectively) and biopsy negative controls (P for a linear trend = 0.03 and 0.05, respectively). There was no interaction between alcohol consumption and folate intake. These analyses support an inverse association between dietary folate intake and prostate cancer risk and primarily risk of high-grade prostate cancer.
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U2 - 10.1080/01635580902846593
DO - 10.1080/01635580902846593
M3 - Article
C2 - 19838935
AN - SCOPUS:70449633167
SN - 0163-5581
VL - 61
SP - 617
EP - 628
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 5
ER -