Formylated polyamines as peptidomimetics

Sacha Javor, Aaron Janowsky, Robert Johnson, Katherine Wolfrum, Mitra Tadayoni-Rebek, Julius Rebek

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A new construct for imitating a natural peptide ligand using a modified retro-inverso sequence is described. It is demonstrated through the synthesis of a peptidomimetic derived from the endogenous sequence of leucine enkephalin. The product was active at 400 nM and selective for μ-opioid receptors.

Original languageEnglish (US)
Pages (from-to)6580-6582
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number21
StatePublished - Nov 1 2012


  • Formylated amines
  • Peptide mimetic
  • Peptides
  • Polyamine
  • Retro-inverso peptide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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