TY - JOUR
T1 - Frequency of and Significance of Physical Frailty in Patients With Heart Failure
AU - Denfeld, Quin E.
AU - Winters-Stone, Kerri
AU - Mudd, James O.
AU - Hiatt, Shirin O.
AU - Chien, Christopher V.
AU - Lee, Christopher S.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/4/15
Y1 - 2017/4/15
N2 - Physical frailty is an important prognostic indicator in heart failure (HF); however, few studies have examined the relation between physical frailty and invasive hemodynamics among adults with HF. The purpose of this study was to characterize physical frailty in HF in relation to invasive hemodynamics. We enrolled 49 patients with New York Heart Association class II to IV HF when participants were scheduled for a right-sided cardiac heart catheterization procedure. Physical frailty was measured according to the “frailty phenotype”: shrinking, weakness, slowness, physical exhaustion, and low physical activity. Markers of invasive hemodynamics were derived from a formal review of right-sided cardiac catheterization tracings, and projected survival was calculated using the Seattle HF model. The mean age of the sample (n = 49) was 57.4 ± 9.7 years, 67% were men, 92% had New York Heart Association class III/IV HF, and 67% had nonischemic HF. Physical frailty was identified in 24 participants (49%) and was associated with worse Seattle HF model 1-year projected survival (p = 0.007). After adjusting for projected survival, physically frail participants had lower cardiac index (by both thermodilution and the Fick equation) and higher heart rates compared with those not physically frail (all p <0.05). In conclusion, physical frailty is highly prevalent in patients with HF and is associated with low-output HF.
AB - Physical frailty is an important prognostic indicator in heart failure (HF); however, few studies have examined the relation between physical frailty and invasive hemodynamics among adults with HF. The purpose of this study was to characterize physical frailty in HF in relation to invasive hemodynamics. We enrolled 49 patients with New York Heart Association class II to IV HF when participants were scheduled for a right-sided cardiac heart catheterization procedure. Physical frailty was measured according to the “frailty phenotype”: shrinking, weakness, slowness, physical exhaustion, and low physical activity. Markers of invasive hemodynamics were derived from a formal review of right-sided cardiac catheterization tracings, and projected survival was calculated using the Seattle HF model. The mean age of the sample (n = 49) was 57.4 ± 9.7 years, 67% were men, 92% had New York Heart Association class III/IV HF, and 67% had nonischemic HF. Physical frailty was identified in 24 participants (49%) and was associated with worse Seattle HF model 1-year projected survival (p = 0.007). After adjusting for projected survival, physically frail participants had lower cardiac index (by both thermodilution and the Fick equation) and higher heart rates compared with those not physically frail (all p <0.05). In conclusion, physical frailty is highly prevalent in patients with HF and is associated with low-output HF.
UR - http://www.scopus.com/inward/record.url?scp=85012880383&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85012880383&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2016.12.024
DO - 10.1016/j.amjcard.2016.12.024
M3 - Article
C2 - 28209349
AN - SCOPUS:85012880383
SN - 0002-9149
VL - 119
SP - 1243
EP - 1249
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 8
ER -