FSH suppression during short term hCG administration: A gonadally mediated process

Edward O. Reiter, Howard E. Kulin, D. Lynn Loriaux

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Plasma and urinary follicle stimuulating hormone, plasma estradiol, and plasma testosterone were measured prior to and after a 4-day hCG provocative test (4000 IU/day) in 6 normal men and in 5 patients with deficient gonadal steroidogenesis ("agonadal"). Plasma and urinary FSH decreased significantly (p < .01) after hCG treatment in the normal men but did not change in the "agonadal" subjects. Mean plasma estradiol rose from 33.4 pg/ml to 73.4 pg/ml and mean plasma testosterone rose from 492 ng/100 ml to 971 ng/100 ml in the normal men; no steroid changes were demonstrable in the "agonadal" group. Additionally, the concomitant administration of clomiphene with hCG prevented the hCG induced FSH suppression in 3 normal men. FSH suppression during shortterm hCG administration to normal men is probably due to negative feedback by testicular steroids.

Original languageEnglish (US)
Pages (from-to)1080-1084
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
StatePublished - 1972
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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