GABA agonist: Clomethiazole

Anand Vaishnav, Helmi L. Lutsep

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Neuroprotective agents inhibit reactions in the brain ischaemic injury cascade which lead to neuronal death. Gamma-aminobutyric acid (GABA) is a naturally occurring inhibitory neurotransmitter that increases chloride influx into the neuron and counteracts the toxic effects of glutamate. Clomethiazole is a GABAA agonist, which causes membrane hyperpolarization, counteracting depolarization and the subsequent cascade of biochemical events that result in neuronal death. Promising results in animal models resulted in clinical trials conducted in humans. However, large randomized placebo controlled trials in Europe, Canada and North America did not show the superiority of clomethiazole over placebo that was seen in animal models.

Original languageEnglish (US)
Pages (from-to)s5-s8
JournalCurrent Medical Research and Opinion
Issue numberSUPPL. 2
StatePublished - 2002


  • Clomethiazole
  • GABA
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)


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