TY - JOUR
T1 - Gender and the injured brain
AU - Vagnerova, Kamila
AU - Koerner, Ines P.
AU - Hurn, Patricia D.
PY - 2008/7
Y1 - 2008/7
N2 - Anesthesiologists are frequently confronted with patients who are at risk for neurological complications due to perioperative stroke or prior traumatic brain injury. In this review, we address the growing and fascinating body of data that suggests gender and sex steroids influence the pathophysiology of injury and outcome for these patients. Cerebral ischemia, traumatic brain injury, and epilepsy are reviewed in the context of potential sex differences in mechanisms and outcomes of brain injury and the role of estrogen, progesterone, and androgens in shaping these processes. Lastly, implications for current and future perioperative and intensive care are identified.
AB - Anesthesiologists are frequently confronted with patients who are at risk for neurological complications due to perioperative stroke or prior traumatic brain injury. In this review, we address the growing and fascinating body of data that suggests gender and sex steroids influence the pathophysiology of injury and outcome for these patients. Cerebral ischemia, traumatic brain injury, and epilepsy are reviewed in the context of potential sex differences in mechanisms and outcomes of brain injury and the role of estrogen, progesterone, and androgens in shaping these processes. Lastly, implications for current and future perioperative and intensive care are identified.
UR - http://www.scopus.com/inward/record.url?scp=49849106412&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49849106412&partnerID=8YFLogxK
U2 - 10.1213/ane.0b013e31817326a5
DO - 10.1213/ane.0b013e31817326a5
M3 - Review article
C2 - 18635489
AN - SCOPUS:49849106412
SN - 0003-2999
VL - 107
SP - 201
EP - 214
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 1
ER -