Gender, sex steroids, and cerebral ischemic pathobiology

I. P. Koerner; S. J. Murphy; P. D. Hurn

doi:10.1007/978-0-387-30383-3_11

Gender, sex steroids, and cerebral ischemic pathobiology

I. P. Koerner, S. J. Murphy, P. D. Hurn

Anesthesiology and Perioperative Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Biological sex is an important genetic determinant of outcome from cerebral ischemia and clinical stroke. Emerging data suggest that sex, as well as reproductive steroids, shapes ischemic cell death in brain. Female sex steroids, the estrogens and progesterone, provide robust neuroprotection in a variety of experimental settings and strongly contribute to sex-specific responses to ischemia. The purpose of this chapter is: (1) to review the importance of biological sex to ischemic outcome and mechanisms of brain injury, (2) to evaluate the role of female sex steroids as endogenous or exogenous ischemic neuroprotectants, and (3) to review most likely mechanisms by which female sex steroids act to interrupt ischemic cell death pathways.

Original language	English (US)
Title of host publication	Handbook of Neurochemistry and Molecular Neurobiology
Subtitle of host publication	Acute Ischemic Injury and Repair in the Nervous System
Publisher	Springer US
Pages	185-207
Number of pages	23
ISBN (Print)	9780387303468
DOIs	https://doi.org/10.1007/978-0-387-30383-3_11
State	Published - 2007

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-0-387-30383-3_11

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AB - Biological sex is an important genetic determinant of outcome from cerebral ischemia and clinical stroke. Emerging data suggest that sex, as well as reproductive steroids, shapes ischemic cell death in brain. Female sex steroids, the estrogens and progesterone, provide robust neuroprotection in a variety of experimental settings and strongly contribute to sex-specific responses to ischemia. The purpose of this chapter is: (1) to review the importance of biological sex to ischemic outcome and mechanisms of brain injury, (2) to evaluate the role of female sex steroids as endogenous or exogenous ischemic neuroprotectants, and (3) to review most likely mechanisms by which female sex steroids act to interrupt ischemic cell death pathways.

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Gender, sex steroids, and cerebral ischemic pathobiology

Abstract

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