Gender, sex steroids, and cerebral ischemic pathobiology

I. P. Koerner, S. J. Murphy, P. D. Hurn

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Biological sex is an important genetic determinant of outcome from cerebral ischemia and clinical stroke. Emerging data suggest that sex, as well as reproductive steroids, shapes ischemic cell death in brain. Female sex steroids, the estrogens and progesterone, provide robust neuroprotection in a variety of experimental settings and strongly contribute to sex-specific responses to ischemia. The purpose of this chapter is: (1) to review the importance of biological sex to ischemic outcome and mechanisms of brain injury, (2) to evaluate the role of female sex steroids as endogenous or exogenous ischemic neuroprotectants, and (3) to review most likely mechanisms by which female sex steroids act to interrupt ischemic cell death pathways.

Original languageEnglish (US)
Title of host publicationHandbook of Neurochemistry and Molecular Neurobiology
Subtitle of host publicationAcute Ischemic Injury and Repair in the Nervous System
PublisherSpringer US
Number of pages23
ISBN (Print)9780387303468
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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