@article{2e2275c66df24d6ea74e847dddb8876e,
title = "Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation",
abstract = "Gene regulatory networks underlie biological function and cellular physiology. Alternative splicing (AS) is a fundamental step in gene regulatory networks and plays a key role in development and disease. In addition to the identification of aberrant AS events, an increasing number of studies are focusing on molecular determinants of AS, including genetic and epigenetic regulators. We review here recent efforts to identify various deregulated AS events as well as their molecular determinants that alter biological functions, and discuss clinical features of AS and their druggable potential.",
keywords = "alternative splicing, computational and experimental methods, gene regulatory networks, genetic and epigenetic, molecular regulators",
author = "Yongsheng Li and McGrail, {Daniel J.} and Juan Xu and Mills, {Gordon B.} and Nidhi Sahni and Song Yi",
note = "Funding Information: This work was supported by a Cancer Prevention and Research Institute of Texas (CPRIT) New Investigator Grant RR160021 (N.S.), a University of Texas System Rising STARs award (N.S.), an AASLD (American Association for the Study of Liver Diseases) Foundation Pinnacle Research Award in Liver Disease (N.S.), the University Center Foundation via the Institutional Research Grant program at the University of Texas MD Anderson Cancer Center (N.S.), and a National Institutes of Health (NIH)/National Cancer Institute (NCI) Transition Career Development Award Grant 1K22CA214765 (S.Y.). Y.L. is supported by a postdoctoral fellowship from the Harold C. and Mary L. Daily Endowment Fund. Additional funding was provided by the Susan G. Komen organization (PDF17483544) to D.J.M. We would like to apologize to all our colleagues whose important work could not be cited here owing to space restrictions. We also thank anonymous reviewers for their constructive feedback to improve the paper. Funding Information: This work was supported by a Cancer Prevention and Research Institute of Texas (CPRIT) New Investigator Grant RR160021 (N.S.), a University of Texas System Rising STARs award (N.S.), an AASLD (American Association for the Study of Liver Diseases) Foundation Pinnacle Research Award in Liver Disease (N.S.), the University Center Foundation via the Institutional Research Grant program at the University of Texas MD Anderson Cancer Center (N.S.), and a National Institutes of Health (NIH)/National Cancer Institute (NCI) Transition Career Development Award Grant 1K22CA214765 (S.Y.). Y.L. is supported by a postdoctoral fellowship from the Harold C. and Mary L. Daily Endowment Fund . Additional funding was provided by the Susan G. Komen organization ( PDF17483544 ) to D.J.M. We would like to apologize to all our colleagues whose important work could not be cited here owing to space restrictions. We also thank anonymous reviewers for their constructive feedback to improve the paper. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = aug,
doi = "10.1016/j.tibs.2018.05.002",
language = "English (US)",
volume = "43",
pages = "576--592",
journal = "Trends in Biochemical Sciences",
issn = "0968-0004",
publisher = "Elsevier Limited",
number = "8",
}