Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation

Yongsheng Li, Daniel J. McGrail, Juan Xu, Gordon B. Mills, Nidhi Sahni, Song Yi

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Gene regulatory networks underlie biological function and cellular physiology. Alternative splicing (AS) is a fundamental step in gene regulatory networks and plays a key role in development and disease. In addition to the identification of aberrant AS events, an increasing number of studies are focusing on molecular determinants of AS, including genetic and epigenetic regulators. We review here recent efforts to identify various deregulated AS events as well as their molecular determinants that alter biological functions, and discuss clinical features of AS and their druggable potential.

Original languageEnglish (US)
Pages (from-to)576-592
Number of pages17
JournalTrends in Biochemical Sciences
Issue number8
StatePublished - Aug 2018
Externally publishedYes


  • alternative splicing
  • computational and experimental methods
  • gene regulatory networks
  • genetic and epigenetic
  • molecular regulators

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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