Genetic analysis workshop II: Further consideration of segregation and linkage analyses in problem 3

P. L. Kramer; D. B. Altmann; K. K. Kidd

doi:10.1002/gepi.1370010213

Genetic analysis workshop II: Further consideration of segregation and linkage analyses in problem 3

P. L. Kramer, D. B. Altmann, K. K. Kidd

Research output: Contribution to journal › Article › peer-review

Abstract

We analyzed disease‐marker associations in Problem 3 for the Genetic Analysis Workshop II, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 1984]. Certain features that we added to the running of LIPED to facilitate the analyses are discussed. Furthermore, we tested for Mendelian transmission in the hypothetical trait locus and we calculated modified relative risks for marker‐trait genotypes. Some of the problems involved in analyzing complex associations among loci are discussed.

Original language	English (US)
Pages (from-to)	189-193
Number of pages	5
Journal	Genetic Epidemiology
Volume	1
Issue number	2
DOIs	https://doi.org/10.1002/gepi.1370010213
State	Published - 1984
Externally published	Yes

Keywords

linkage analysis
segregation analysis

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/gepi.1370010213

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abstract = "We analyzed disease‐marker associations in Problem 3 for the Genetic Analysis Workshop II, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 1984]. Certain features that we added to the running of LIPED to facilitate the analyses are discussed. Furthermore, we tested for Mendelian transmission in the hypothetical trait locus and we calculated modified relative risks for marker‐trait genotypes. Some of the problems involved in analyzing complex associations among loci are discussed.",

keywords = "linkage analysis, segregation analysis",

author = "Kramer, {P. L.} and Altmann, {D. B.} and Kidd, {K. K.}",

year = "1984",

doi = "10.1002/gepi.1370010213",

language = "English (US)",

volume = "1",

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journal = "Genetic Epidemiology",

issn = "0741-0395",

publisher = "Wiley-Liss Inc.",

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T2 - Further consideration of segregation and linkage analyses in problem 3

AU - Kramer, P. L.

AU - Altmann, D. B.

AU - Kidd, K. K.

PY - 1984

Y1 - 1984

N2 - We analyzed disease‐marker associations in Problem 3 for the Genetic Analysis Workshop II, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 1984]. Certain features that we added to the running of LIPED to facilitate the analyses are discussed. Furthermore, we tested for Mendelian transmission in the hypothetical trait locus and we calculated modified relative risks for marker‐trait genotypes. Some of the problems involved in analyzing complex associations among loci are discussed.

AB - We analyzed disease‐marker associations in Problem 3 for the Genetic Analysis Workshop II, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 1984]. Certain features that we added to the running of LIPED to facilitate the analyses are discussed. Furthermore, we tested for Mendelian transmission in the hypothetical trait locus and we calculated modified relative risks for marker‐trait genotypes. Some of the problems involved in analyzing complex associations among loci are discussed.

KW - linkage analysis

KW - segregation analysis

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JF - Genetic Epidemiology

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ER -

Genetic analysis workshop II: Further consideration of segregation and linkage analyses in problem 3

Abstract

Keywords

ASJC Scopus subject areas

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