@article{217e25c50ece41cb936ac0fd7e17186b,
title = "Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine",
abstract = "Patients with pancreatic ductal adenocarcinoma (PDA) have a poor prognosis despite new treatments; approximately 7% survive for 5 years. Although there have been advances in systemic, primarily cytotoxic, therapies, it has been a challenge to treat patients with PDA using targeted therapies. Sequence analyses have provided a wealth of information about the genetic features of PDA and have identified potential therapeutic targets. Preclinical and early-phase clinical studies have found specific pathways could be rationally targeted; it might also be possible to take advantage of the genetic diversity of PDAs to develop therapeutic agents. The genetic diversity and instability of PDA cells have long been thought of as obstacles to treatment, but are now considered exploitable features. We review the latest findings in pancreatic cancer genetics and the promise of targeted approaches in PDA therapy.",
keywords = "Kras, Myc, Notch, Smad4",
author = "Knudsen, {Erik S.} and O'Reilly, {Eileen M.} and Brody, {Jonathan R.} and Witkiewicz, {Agnieszka K.}",
note = "Funding Information: The authors thank their colleagues and collaborators for thought-provoking discussions related to the use of genetic features of disease to provide clues to treatment. Any oversight of citations is unintended, and all efforts were made to provide a comprehensive and unbiased review of the field and to consider paths forward. The authors thank Uthra Balaji (University of Texas Southwestern Medical Center) and Sarah Williamson (Gastroenterology) for informatic and graphical assistance, respectively. This study was supported by grants from the National Institutes of Health NIHCA142543-05S2 (Erik S. Knudsen), NIH-CA182692 (Jonathan R. Brody), and NIH-CA142543-05S2 (Agnieszka K. Witkiewicz), Andrea J. Will Foundation (Eileen M. O''Reilly), and American Association for Cancer Research Pancreatic Cancer Action Network Research Acceleration Network grant (Jonathan R. Brody). Publisher Copyright: {\textcopyright} 2016 AGA Institute.",
year = "2016",
month = jan,
day = "1",
doi = "10.1053/j.gastro.2015.08.056",
language = "English (US)",
volume = "150",
pages = "48--63",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "1",
}