Genetic linkage is excluded for the D2-dopamine receptor λHD2G1 and flanking loci on chromosome 11q22-q23 in tourette syndrome

Eric J. Devor; David K. Grandy; Olivier Civelli; Michael Litl; Andrea K. Burgess; Keith E. Isenberg; B. J.M. Van De Wetering; Ben Oostra

doi:10.1159/000153914

Genetic linkage is excluded for the D₂-dopamine receptor λHD2G1 and flanking loci on chromosome 11q22-q23 in tourette syndrome

Eric J. Devor, David K. Grandy, Olivier Civelli, Michael Litl, Andrea K. Burgess, Keith E. Isenberg, B. J.M. Van De Wetering, Ben Oostra

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D₂dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.

Original language	English (US)
Pages (from-to)	105-108
Number of pages	4
Journal	Human Heredity
Volume	40
Issue number	2
DOIs	https://doi.org/10.1159/000153914
State	Published - 1990

Keywords

Chromosome 11q
Linkage
Tourette syndrome

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Access to Document

10.1159/000153914

Cite this

@article{f1e889521e8c402fa9e71d58c1807ab6,

title = "Genetic linkage is excluded for the D2-dopamine receptor λHD2G1 and flanking loci on chromosome 11q22-q23 in tourette syndrome",

abstract = "A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.",

keywords = "Chromosome 11q, Linkage, Tourette syndrome",

author = "Devor, {Eric J.} and Grandy, {David K.} and Olivier Civelli and Michael Litl and Burgess, {Andrea K.} and Isenberg, {Keith E.} and {Van De Wetering}, {B. J.M.} and Ben Oostra",

year = "1990",

doi = "10.1159/000153914",

language = "English (US)",

volume = "40",

pages = "105--108",

journal = "Human Heredity",

issn = "0001-5652",

publisher = "S. Karger AG",

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TY - JOUR

T1 - Genetic linkage is excluded for the D2-dopamine receptor λHD2G1 and flanking loci on chromosome 11q22-q23 in tourette syndrome

AU - Devor, Eric J.

AU - Grandy, David K.

AU - Civelli, Olivier

AU - Litl, Michael

AU - Burgess, Andrea K.

AU - Isenberg, Keith E.

AU - Van De Wetering, B. J.M.

AU - Oostra, Ben

PY - 1990

Y1 - 1990

N2 - A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.

AB - A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.

KW - Chromosome 11q

KW - Linkage

KW - Tourette syndrome

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DO - 10.1159/000153914

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VL - 40

SP - 105

EP - 108

JO - Human Heredity

JF - Human Heredity

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