Genetically obese zucker rats have abnormally low brain insulin content

Denis G. Baskin, Leslie J. Stein, Hitoshi Ikeda, Stephen C. Woods, Dianne P. Figlewicz, Daniel Porte, M. R.C. Greenwood, Daniel M. Dorsa

Research output: Contribution to journalArticlepeer-review

125 Scopus citations


The concentration of immunoreactive insulin (IRI) extracted from the olfactory bulb, hypothalamus, hippocampus, cerebral cortex, amygdala, midbrain, and hindbrain was significantly lower in obese (fa/fa) and heterozygous (Fa/fa) Zucker rats in comparison to lean (Fa/Fa) Zucker rats. This deficit in brain IRI content was most severe in the hypothalamus and olfactory bulb and was independent of severe obesity since the marked reduction of brain IRI content was also found in heterozygous rats which possessed only one copy of the fa allele. These results demonstrate that in the 2-3 month-old female Zucker rat, the fa allele is associated with defective regulation of insulin in the brain.

Original languageEnglish (US)
Pages (from-to)627-633
Number of pages7
JournalLife Sciences
Issue number7
StatePublished - Feb 18 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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