Genetics of age-related macular degeneration

Michael L. Klein, Peter J. Francis

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Gene discoveries will lead to more effective therapies for AIMED by identifying specific underlying disease mechanisms that might be corrected by drugs or gene therapy. For example, investigations are currently being carried out using pigment epithelium-derived factor (PEDE). The gene for this potent inhibitor of angiogenesis has been incorporated into an adenoviral vector and delivered into the eye by intravitreal injection [95] to inhibit growth of new blood vessels in eyes with neovascular AMD. In the future, as the genetics of this complex disease are unraveled, more effective treatments and preventative measures that target specific molecular defects underlying the development of AMD can be expected.

Original languageEnglish (US)
Pages (from-to)567-574
Number of pages8
JournalOphthalmology Clinics of North America
Issue number4
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Ophthalmology


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