TY - JOUR
T1 - Genetics of mouse behavior
T2 - Interactions with laboratory environment
AU - Crabbe, John C.
AU - Wahlsten, Douglas
AU - Dudek, Bruce C.
PY - 1999/6/4
Y1 - 1999/6/4
N2 - Strains of mice that show characteristic patterns of behavior are critical for research in neurobehavioral genetics. Possible confounding influences of the laboratory environment were studied in several inbred strains and one null mutant by simultaneous testing in three laboratories on a battery of six behaviors. Apparatus, test protocols, and many environmental variables were rigorously equated. Strains differed markedly in all behaviors, and despite standardization, there were systematic differences in behavior across labs. For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory.
AB - Strains of mice that show characteristic patterns of behavior are critical for research in neurobehavioral genetics. Possible confounding influences of the laboratory environment were studied in several inbred strains and one null mutant by simultaneous testing in three laboratories on a battery of six behaviors. Apparatus, test protocols, and many environmental variables were rigorously equated. Strains differed markedly in all behaviors, and despite standardization, there were systematic differences in behavior across labs. For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory.
UR - http://www.scopus.com/inward/record.url?scp=0033523043&partnerID=8YFLogxK
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U2 - 10.1126/science.284.5420.1670
DO - 10.1126/science.284.5420.1670
M3 - Article
C2 - 10356397
AN - SCOPUS:0033523043
SN - 0036-8075
VL - 284
SP - 1670
EP - 1672
JO - Science
JF - Science
IS - 5420
ER -