Genome typing of nonhuman primate models: Implications for biomedical research

Tanja Haus, Betsy Ferguson, Jeffrey Rogers, Gaby Doxiadis, Ulrich Certa, Nicola J. Rose, Robert Teepe, Gerhard F. Weinbauer, Christian Roos

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

The success of personalized medicine rests on understanding the genetic variation between individuals. Thus, as medical practice evolves and variation among individuals becomes a fundamental aspect of clinical medicine, a thorough consideration of the genetic and genomic information concerning the animals used as models in biomedical research also becomes critical. In particular, nonhuman primates (NHPs) offer great promise as models for many aspects of human health and disease. These are outbred species exhibiting substantial levels of genetic variation; however, understanding of the contribution of this variation to phenotypes is lagging behind in NHP species. Thus, there is a pivotal need to address this gap and define strategies for characterizing both genomic content and variability within primate models of human disease. Here, we discuss the current state of genomics of NHP models and offer guidelines for future work to ensure continued improvement and utility of this line of biomedical research.

Original languageEnglish (US)
Pages (from-to)482-487
Number of pages6
JournalTrends in Genetics
Volume30
Issue number11
DOIs
StatePublished - 2014

Keywords

  • Biomedicine
  • Breeding management
  • Genetic variation
  • Genomics
  • Genotyping
  • Primates

ASJC Scopus subject areas

  • Genetics

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