Global Electrical Heterogeneity: Mechanisms and Clinical Significance

Larisa G. Tereshchenko

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    3 Scopus citations


    This review summarizes recent findings and discusses a clinical significance of a vectorcardiographic (VCG) Global electrical heterogeneity (GEH). GEH concept is based on the concept of the spatial ventricular gradient (SVG), which is a global measure of the dispersion of total recovery time. We quantify GEH by measuring five features of the SVG vector (SVG magnitude, direction (azimuth and elevation), a scalar value, and spatial QRS-T angle) on orthogonal XYZ ECG. In analysis of more than 20,000 adults we showed that GEH is independently associated with sudden cardiac death (SCD) after adjustment for demographics, cardiovascular disease (time-updated incident non-fatal cardiovascular events [coronary heart disease, heart failure, stroke, atrial fibrillation, use of beta-blockers], and known risk factors [cholesterol, triglycerides, physical activity index, smoking, diabetes, obesity, hypertension, antihypertensive medications, creatinine, alcohol intake, left ventricular ejection fraction, and time-updated ECG metrics (heart rate, QTc, QRS duration, ECG-left ventricular hypertrophy, bundle branch block or interventricular conduction delay)]. This finding suggests that GEH represents an independent electrophysiological substrate of SCD.

    Original languageEnglish (US)
    Title of host publicationComputing in Cardiology Conference, CinC 2018
    PublisherIEEE Computer Society
    ISBN (Electronic)9781728109589
    StatePublished - Sep 2018
    Event45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Netherlands
    Duration: Sep 23 2018Sep 26 2018

    Publication series

    NameComputing in Cardiology
    ISSN (Print)2325-8861
    ISSN (Electronic)2325-887X


    Conference45th Computing in Cardiology Conference, CinC 2018

    ASJC Scopus subject areas

    • Computer Science(all)
    • Cardiology and Cardiovascular Medicine


    Dive into the research topics of 'Global Electrical Heterogeneity: Mechanisms and Clinical Significance'. Together they form a unique fingerprint.

    Cite this