TY - JOUR
T1 - Glucagonoma syndrome
T2 - In vitro evidence that glucagon increases epidermal arachidonic acid
AU - Peterson, Larry L.
AU - Shaw, James C.
AU - Acott, Karen M.
AU - Mueggler, Paul A.
AU - Parker, Frank
PY - 1984
Y1 - 1984
N2 - A 63-year-old white woman with perioral dermatitis, a sore tongue, and an erythematous dermatosis in the inframammary and perineal regions underwent surgical removal of a pancreatic glucagonoma. The patient's plasma and pooled normal human plasma containing Sigma glucagon were fed to human keratinocyte cultures and increased arachidonic acid levels by 300% and 200%, respectively, when compared to pooled normal human plasma with no added commercial glucagon. These experiments suggest that glucagon may increase inflammatory mediators such as arachidonic acid and its metabolites in the epidermis, causing the skin lesions seen in the glucagonoma syndrome.
AB - A 63-year-old white woman with perioral dermatitis, a sore tongue, and an erythematous dermatosis in the inframammary and perineal regions underwent surgical removal of a pancreatic glucagonoma. The patient's plasma and pooled normal human plasma containing Sigma glucagon were fed to human keratinocyte cultures and increased arachidonic acid levels by 300% and 200%, respectively, when compared to pooled normal human plasma with no added commercial glucagon. These experiments suggest that glucagon may increase inflammatory mediators such as arachidonic acid and its metabolites in the epidermis, causing the skin lesions seen in the glucagonoma syndrome.
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U2 - 10.1016/S0190-9622(84)70192-7
DO - 10.1016/S0190-9622(84)70192-7
M3 - Article
C2 - 6090515
AN - SCOPUS:0021165852
SN - 0190-9622
VL - 11
SP - 468
EP - 473
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 3
ER -