Glutamate release monitored with astrocyte transporter currents during LTP

Jeffrey S. Diamond; Dwight E. Bergles; Craig E. Jahr

doi:10.1016/S0896-6273(00)80551-6

Glutamate release monitored with astrocyte transporter currents during LTP

Jeffrey S. Diamond
, Dwight E. Bergles
, Craig E. Jahr

Vollum Institute

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Abstract

Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is thought to result from either increased transmitter release, heightened postsynaptic sensitivity, or a combination of the two. We have measured evoked glutamate release from Schaffer collateral/commissural fiber terminals in CA1 by recording synaptically activated glutamate transporter currents in hippocampal astrocytes located in stratum radiatum. Although several manipulations of release probability caused parallel changes in extracellular field potentials and synaptically activated transporter current amplitudes, induction of LTP failed to alter transporter-mediated responses, suggesting that LTP does not alter the amount of glutamate released upon synaptic stimulation.

Original language	English (US)
Pages (from-to)	425-433
Number of pages	9
Journal	Neuron
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/S0896-6273(00)80551-6
State	Published - Aug 1998

Funding

This work was supported by National Institutes of Health grants NS10041 (J. S. D.) and NS21419 (C. E. J.). We thank J. Dzubay, M. Kavanaugh, T. Otis, and J. Williams for critically reading the manuscript.

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	NS10041
National Institute of Neurological Disorders and Stroke	R01NS021419

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0896-6273(00)80551-6

Cite this

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title = "Glutamate release monitored with astrocyte transporter currents during LTP",

abstract = "Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is thought to result from either increased transmitter release, heightened postsynaptic sensitivity, or a combination of the two. We have measured evoked glutamate release from Schaffer collateral/commissural fiber terminals in CA1 by recording synaptically activated glutamate transporter currents in hippocampal astrocytes located in stratum radiatum. Although several manipulations of release probability caused parallel changes in extracellular field potentials and synaptically activated transporter current amplitudes, induction of LTP failed to alter transporter-mediated responses, suggesting that LTP does not alter the amount of glutamate released upon synaptic stimulation.",

author = "Diamond, \{Jeffrey S.\} and Bergles, \{Dwight E.\} and Jahr, \{Craig E.\}",

note = "Funding Information: This work was supported by National Institutes of Health grants NS10041 (J. S. D.) and NS21419 (C. E. J.). We thank J. Dzubay, M. Kavanaugh, T. Otis, and J. Williams for critically reading the manuscript.",

year = "1998",

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doi = "10.1016/S0896-6273(00)80551-6",

language = "English (US)",

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T1 - Glutamate release monitored with astrocyte transporter currents during LTP

AU - Diamond, Jeffrey S.

AU - Bergles, Dwight E.

AU - Jahr, Craig E.

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N2 - Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is thought to result from either increased transmitter release, heightened postsynaptic sensitivity, or a combination of the two. We have measured evoked glutamate release from Schaffer collateral/commissural fiber terminals in CA1 by recording synaptically activated glutamate transporter currents in hippocampal astrocytes located in stratum radiatum. Although several manipulations of release probability caused parallel changes in extracellular field potentials and synaptically activated transporter current amplitudes, induction of LTP failed to alter transporter-mediated responses, suggesting that LTP does not alter the amount of glutamate released upon synaptic stimulation.

AB - Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is thought to result from either increased transmitter release, heightened postsynaptic sensitivity, or a combination of the two. We have measured evoked glutamate release from Schaffer collateral/commissural fiber terminals in CA1 by recording synaptically activated glutamate transporter currents in hippocampal astrocytes located in stratum radiatum. Although several manipulations of release probability caused parallel changes in extracellular field potentials and synaptically activated transporter current amplitudes, induction of LTP failed to alter transporter-mediated responses, suggesting that LTP does not alter the amount of glutamate released upon synaptic stimulation.

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Glutamate release monitored with astrocyte transporter currents during LTP

Abstract

Funding

ASJC Scopus subject areas

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