Glycine-bound NMDA receptors are stretch-activated

Research output: Contribution to journalShort surveypeer-review


In a recent study, Belin et al. demonstrated that glycine-bound NMDA receptors can be activated by mechanical forces in the absence of the neurotransmitter glutamate. The stretch-gated receptor exhibits biophysical properties similar to those of glutamate-gated receptors. These findings reveal that glycine-bound NMDA receptors could behave as mechanosensors in central nervous system (CNS) physiology.

Original languageEnglish (US)
Pages (from-to)794-795
Number of pages2
JournalTrends in Neurosciences
Issue number11
StatePublished - Nov 2022


  • NMDA receptors
  • mechanically activated ion channels
  • mechanosensation

ASJC Scopus subject areas

  • Neuroscience(all)


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