Glycine-bound NMDA receptors are stretch-activated

Swetha E. Murthy

doi:10.1016/j.tins.2022.08.002

Glycine-bound NMDA receptors are stretch-activated

Swetha E. Murthy

Vollum Institute

Research output: Contribution to journal › Short survey › peer-review

Abstract

In a recent study, Belin et al. demonstrated that glycine-bound NMDA receptors can be activated by mechanical forces in the absence of the neurotransmitter glutamate. The stretch-gated receptor exhibits biophysical properties similar to those of glutamate-gated receptors. These findings reveal that glycine-bound NMDA receptors could behave as mechanosensors in central nervous system (CNS) physiology.

Original language	English (US)
Pages (from-to)	794-795
Number of pages	2
Journal	Trends in Neurosciences
Volume	45
Issue number	11
DOIs	https://doi.org/10.1016/j.tins.2022.08.002
State	Published - Nov 2022

Keywords

NMDA receptors
mechanically activated ion channels
mechanosensation

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.tins.2022.08.002

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title = "Glycine-bound NMDA receptors are stretch-activated",

abstract = "In a recent study, Belin et al. demonstrated that glycine-bound NMDA receptors can be activated by mechanical forces in the absence of the neurotransmitter glutamate. The stretch-gated receptor exhibits biophysical properties similar to those of glutamate-gated receptors. These findings reveal that glycine-bound NMDA receptors could behave as mechanosensors in central nervous system (CNS) physiology.",

keywords = "NMDA receptors, mechanically activated ion channels, mechanosensation",

author = "Murthy, {Swetha E.}",

note = "Funding Information: The author thanks Dr Paul Brehm for helpful comments. S.E.M. is funded by the Silver Family Foundation . Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

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language = "English (US)",

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AB - In a recent study, Belin et al. demonstrated that glycine-bound NMDA receptors can be activated by mechanical forces in the absence of the neurotransmitter glutamate. The stretch-gated receptor exhibits biophysical properties similar to those of glutamate-gated receptors. These findings reveal that glycine-bound NMDA receptors could behave as mechanosensors in central nervous system (CNS) physiology.

KW - NMDA receptors

KW - mechanically activated ion channels

KW - mechanosensation

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JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 11

ER -

Glycine-bound NMDA receptors are stretch-activated

Abstract

Keywords

ASJC Scopus subject areas

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