In a recent study, Belin et al. demonstrated that glycine-bound NMDA receptors can be activated by mechanical forces in the absence of the neurotransmitter glutamate. The stretch-gated receptor exhibits biophysical properties similar to those of glutamate-gated receptors. These findings reveal that glycine-bound NMDA receptors could behave as mechanosensors in central nervous system (CNS) physiology.
|Original language||English (US)|
|Number of pages||2|
|Journal||Trends in Neurosciences|
|State||Published - Nov 2022|
- NMDA receptors
- mechanically activated ion channels
ASJC Scopus subject areas