Abstract
Dopaminergic and non-dopaminergic neurons of the ventral tegmental area (VTA) were recorded intracellularly in slices of rat midbrain. Glycine (0.1-3 mM) caused a strychnine-sensitive and chloride-dependent reduction in membrane input resistance in both types of neuron. However, glycine also reduced the frequency of spontaneous bicuculline-sensitive inhibitory postsynaptic potentials (IPSPs) when recorded in dopaminergic cells. We conclude that glycine inhibits both types of VTA neuron by activating a strychnine-sensitive chloride conductance. Our data also raise the possibility that glycine could increase dopamine output from the VTA by a mechanism of disinhibition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 313-317 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 919 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 23 2001 |
Funding
This work is supported by US Public Health Service Grant MH40416.
| Funders | Funder number |
|---|---|
| US Public Health Service | |
| National Institutes of Health National Institute of Mental Health | R01MH040416 |
Keywords
- Dopamine neuron
- GABA
- Glycine
- Strychnine
- Ventral tegmental area
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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