Glycinergic Transmission Shaped by the Corelease of GABA in a Mammalian Auditory Synapse

Tao Lu, Maria E. Rubio, Laurence O. Trussell

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


The firing pattern of neurons is shaped by the convergence of excitation and inhibition, each with finely tuned magnitude and duration. In an auditory brainstem nucleus, glycinergic inhibition features fast decay kinetics, the mechanism of which is unknown. By applying glycine to native or recombinant glycine receptors, we show that response decay times are accelerated by addition of GABA, a weak partial agonist of glycine receptors. Systematic variation in agonist exposure time revealed that fast synaptic time course may be achieved with submillisecond exposures to mixtures of glycine and GABA at physiological concentrations. Accordingly, presynaptic terminals generally contained both transmitters, and depleting terminals of GABA slowed glycinergic synaptic currents. Thus, coreleased GABA accelerates glycinergic transmission by acting directly on glycine receptors, narrowing the time window for effective inhibition. Packaging both weak and strong agonists in vesicles may be a general means by which presynaptic neurons regulate the duration of postsynaptic responses.

Original languageEnglish (US)
Pages (from-to)524-535
Number of pages12
Issue number4
StatePublished - Feb 28 2008



ASJC Scopus subject areas

  • Neuroscience(all)


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