Glycosphingolipid biosynthesis may not be necessary for vertebrate brain development

John V. Brigande, Thomas N. Seyfried

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Glycosphingolipids (GSLs) in general and gangliosides in particular have long been considered essential for CNS growth and development. Recent studies with intact developing systems in fish and mice challenge this general notion. These studies suggest that glycosphingolipid biosynthesis and expression is neither essential nor necessary for neural growth and differentiation in the developing vertebrate brain. Rather than having a major role in neural cell growth and morphogenesis, the GSLs may have a role in modulating such membrane properties as signaling, electrical conduction, maintenance, and stability.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalAnnals of the New York Academy of Sciences
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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