TY - JOUR
T1 - Going Skin Deep
T2 - Excavating a Diagnosis of Intravascular Large B Cell Lymphoma
AU - Oppegard, Laura
AU - O’Donnell, Matthew
AU - Piro, Kevin
AU - Shatzel, Joseph
AU - Christian, Robert
AU - Raess, Philipp W.
AU - Desai, Sima
N1 - Publisher Copyright:
© 2020, Society of General Internal Medicine.
PY - 2020/11
Y1 - 2020/11
N2 - A fever of unknown origin is often pursued diagnostically under the framework of infectious, rheumatologic, and neoplastic causes. When encephalopathy ensues, the differential diagnosis narrows, but can remain elusive, particularly when dealing with rare diseases. We present the case of a patient with fever of unknown origin and intermittent encephalopathy that spanned multiple hospital admissions and ultimately yielded a diagnosis of intravascular large B cell lymphoma complicated by hemophagocytic lymphohistiocytosis. We review the varying presentations of this disease, when to consider this as a diagnosis, and how to most accurately make the diagnosis.
AB - A fever of unknown origin is often pursued diagnostically under the framework of infectious, rheumatologic, and neoplastic causes. When encephalopathy ensues, the differential diagnosis narrows, but can remain elusive, particularly when dealing with rare diseases. We present the case of a patient with fever of unknown origin and intermittent encephalopathy that spanned multiple hospital admissions and ultimately yielded a diagnosis of intravascular large B cell lymphoma complicated by hemophagocytic lymphohistiocytosis. We review the varying presentations of this disease, when to consider this as a diagnosis, and how to most accurately make the diagnosis.
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U2 - 10.1007/s11606-020-06141-1
DO - 10.1007/s11606-020-06141-1
M3 - Article
C2 - 32815059
AN - SCOPUS:85089697666
SN - 0884-8734
VL - 35
SP - 3368
EP - 3371
JO - Journal of general internal medicine
JF - Journal of general internal medicine
IS - 11
ER -