Going Skin Deep: Excavating a Diagnosis of Intravascular Large B Cell Lymphoma

Laura Oppegard, Matthew O’Donnell, Kevin Piro, Joseph Shatzel, Robert Christian, Philipp W. Raess, Sima Desai

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A fever of unknown origin is often pursued diagnostically under the framework of infectious, rheumatologic, and neoplastic causes. When encephalopathy ensues, the differential diagnosis narrows, but can remain elusive, particularly when dealing with rare diseases. We present the case of a patient with fever of unknown origin and intermittent encephalopathy that spanned multiple hospital admissions and ultimately yielded a diagnosis of intravascular large B cell lymphoma complicated by hemophagocytic lymphohistiocytosis. We review the varying presentations of this disease, when to consider this as a diagnosis, and how to most accurately make the diagnosis.

Original languageEnglish (US)
Pages (from-to)3368-3371
Number of pages4
JournalJournal of general internal medicine
Issue number11
StatePublished - Nov 2020

ASJC Scopus subject areas

  • Internal Medicine


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