Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis

Bruce F. Bebo; Edy Zelinka-Vincent; Grazyna Adamus; Drake Amundson; Arthur A. Vandenbark; Halina Offner

doi:10.1016/S0165-5728(97)00214-2

Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis

Bruce F. Bebo
, Edy Zelinka-Vincent
, Grazyna Adamus
, Drake Amundson
, Arthur A. Vandenbark
, Halina Offner

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139-151 developed an initial episode of paralysis, but failed to relapse. In the present study, clinical EAE relapses were induced by orchidectomy. Relapses in castrated mice were accompanied by an influx of activated CD4⁺, Th1 cells into the CNS which were absent in sham mice. Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE.

Original language	English (US)
Pages (from-to)	122-130
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/S0165-5728(97)00214-2
State	Published - Apr 15 1998

Funding

We are grateful to Dr. David Hess for performing the serum hormone analysis, and Cantab Pharmaceuticals for providing the mouse OX40L-Ig fusion protein. We also thank Dr. Andrew Weinberg and Dr. Charles Roselli for helpful discussions and critical review of this manuscript. This work was supported by the Department of Veterans Affairs and by National Institutes of Health Grants NS 23221 AI42376 and NS23444. B.F.B. is a post-docotoral fellow of the National Multiple Sclerosis Society.

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	NS 23221 AI42376, NS23444
National Institute of Allergy and Infectious Diseases	R01AI042376
U.S. Department of Veterans Affairs

Keywords

Androgens
Orchidectomy
Relapsing experimental autoimmune encephalomyelitis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(97)00214-2

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title = "Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis",

abstract = "Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139-151 developed an initial episode of paralysis, but failed to relapse. In the present study, clinical EAE relapses were induced by orchidectomy. Relapses in castrated mice were accompanied by an influx of activated CD4+, Th1 cells into the CNS which were absent in sham mice. Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE.",

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author = "Bebo, \{Bruce F.\} and Edy Zelinka-Vincent and Grazyna Adamus and Drake Amundson and Vandenbark, \{Arthur A.\} and Halina Offner",

note = "Funding Information: We are grateful to Dr. David Hess for performing the serum hormone analysis, and Cantab Pharmaceuticals for providing the mouse OX40L-Ig fusion protein. We also thank Dr. Andrew Weinberg and Dr. Charles Roselli for helpful discussions and critical review of this manuscript. This work was supported by the Department of Veterans Affairs and by National Institutes of Health Grants NS 23221 AI42376 and NS23444. B.F.B. is a post-docotoral fellow of the National Multiple Sclerosis Society. ",

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AU - Bebo, Bruce F.

AU - Zelinka-Vincent, Edy

AU - Adamus, Grazyna

AU - Amundson, Drake

AU - Vandenbark, Arthur A.

AU - Offner, Halina

N1 - Funding Information: We are grateful to Dr. David Hess for performing the serum hormone analysis, and Cantab Pharmaceuticals for providing the mouse OX40L-Ig fusion protein. We also thank Dr. Andrew Weinberg and Dr. Charles Roselli for helpful discussions and critical review of this manuscript. This work was supported by the Department of Veterans Affairs and by National Institutes of Health Grants NS 23221 AI42376 and NS23444. B.F.B. is a post-docotoral fellow of the National Multiple Sclerosis Society.

PY - 1998/4/15

Y1 - 1998/4/15

N2 - Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139-151 developed an initial episode of paralysis, but failed to relapse. In the present study, clinical EAE relapses were induced by orchidectomy. Relapses in castrated mice were accompanied by an influx of activated CD4+, Th1 cells into the CNS which were absent in sham mice. Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE.

AB - Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139-151 developed an initial episode of paralysis, but failed to relapse. In the present study, clinical EAE relapses were induced by orchidectomy. Relapses in castrated mice were accompanied by an influx of activated CD4+, Th1 cells into the CNS which were absent in sham mice. Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE.

KW - Androgens

KW - Orchidectomy

KW - Relapsing experimental autoimmune encephalomyelitis

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Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis

Abstract

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Keywords

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