GPCRs at Endosomes: Sorting, Signaling, and Recycling

Roshanak Irannejad; Braden T. Lobingier

doi:10.1002/9781119564782.ch6

GPCRs at Endosomes: Sorting, Signaling, and Recycling

Roshanak Irannejad, Braden T. Lobingier

Chemical Physiology and Biochemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

GPCR activity is shaped by the interplay of trafficking and signaling. Receptor location within the cell, and its active movement between organelles, changes the local complement of proteins which mediate and regulate GPCR activity. Here we review our understanding of the mechanisms by which GPCRs are selectively trafficked at the endosome for recycling back to the plasma membrane. We will also highlight recent developments in subcellular signaling of GPCRs from the endosome and how trafficking can shape this activity.

Original language	English (US)
Title of host publication	GPCRs as Therapeutic Targets
Publisher	wiley
Pages	180-196
Number of pages	17
Volume	1
ISBN (Electronic)	9781119564782
ISBN (Print)	9781119564744
DOIs	https://doi.org/10.1002/9781119564782.ch6
State	Published - Jan 1 2021

Keywords

GPCR
degradation
endocytosis
endosome
recycling
signaling
trafficking

ASJC Scopus subject areas

General Chemistry
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1002/9781119564782.ch6

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GPCRs at Endosomes: Sorting, Signaling, and Recycling

Abstract

Keywords

ASJC Scopus subject areas

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