GPCRs at Endosomes: Sorting, Signaling, and Recycling

Roshanak Irannejad, Braden T. Lobingier

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

GPCR activity is shaped by the interplay of trafficking and signaling. Receptor location within the cell, and its active movement between organelles, changes the local complement of proteins which mediate and regulate GPCR activity. Here we review our understanding of the mechanisms by which GPCRs are selectively trafficked at the endosome for recycling back to the plasma membrane. We will also highlight recent developments in subcellular signaling of GPCRs from the endosome and how trafficking can shape this activity.

Original languageEnglish (US)
Title of host publicationGPCRs as Therapeutic Targets
Publisherwiley
Pages180-196
Number of pages17
Volume1
ISBN (Electronic)9781119564782
ISBN (Print)9781119564744
DOIs
StatePublished - Jan 1 2021

Keywords

  • GPCR
  • degradation
  • endocytosis
  • endosome
  • recycling
  • signaling
  • trafficking

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

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