GPCR activity is shaped by the interplay of trafficking and signaling. Receptor location within the cell, and its active movement between organelles, changes the local complement of proteins which mediate and regulate GPCR activity. Here we review our understanding of the mechanisms by which GPCRs are selectively trafficked at the endosome for recycling back to the plasma membrane. We will also highlight recent developments in subcellular signaling of GPCRs from the endosome and how trafficking can shape this activity.
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Biochemistry, Genetics and Molecular Biology(all)