TY - JOUR
T1 - Groin dissections in skin cancer
T2 - Effect of a change in prophylactic antibiotic protocol
AU - Dargan, Dallan
AU - Hindocha, Sandip
AU - Hadlett, Max
AU - Wright, Rosanna
AU - Beck, Deborah
AU - McConville, Sarah
AU - Hartley-Large, David
AU - Mortimer, Kalani
AU - Brackley, Philip
N1 - Publisher Copyright:
© 2020 British Association of Plastic, Reconstructive and Aesthetic Surgeons
PY - 2021/7
Y1 - 2021/7
N2 - Objectives: To determine whether groin dissection surgical site infection (SSI) incidence changed with shorter post-operative antibiotic prophylaxis. Background: Post-operative prophylaxis changed due to antimicrobial stewardship, from regular oral antibiotics until drain removal, to three intravenous doses. Both groups had a single intravenous dose at induction. Methods: A prospective database of groin dissections for metastatic skin cancer was retrospectively reviewed for SSI according to Public Health England criteria. Eighty groin dissections in 79 consecutive patients were included: 40 had oral antibiotics until drain removal [mean 26±7 (range 19–36) days] and 39 had three post-operative intravenous doses. Results: Longer prophylaxis was associated with lower SSI incidence [10 (25%) versus 21 (54%), odds ratio (OR) 3.50, 95% confidence interval (CI) 1.34–9.08, p = 0.009], fewer deep infections [5 (13%) versus 16 (41%), OR 4.89, 95% CI 1.57–15.13, p = 0.004], fewer readmissions for infection [5 (13%) versus 15 (38%), OR 4.38, 95% CI 1.40–13.65, p = 0.008], but similar seroma incidence [18 (45%) versus 16 (41%), OR 0.85, 95% CI 0.35–2.07, p = 0.72] and wound dehiscence [7 (18%) versus 5 (13%), OR 0.69, 95% CI 0.20–2.40, p = 0.56]. BMI ≥30 (n = 21) was associated with SSI, occurring in 13 of 21 (62%) (OR 3.859, 95% CI 1.34–11.10, p = 0.01). Median infection onset was 22 days (IQR 12–27) versus 17 (IQR 13–22), (p = 0.53). Multiple organisms were cultured in 21 of 31 (68%) patients with positive microbiological samples. Conclusions: SSI rates doubled with shorter prophylaxis; deep infections and readmissions for infection tripled. Obesity was independently associated with infection. Seroma and wound dehiscence incidence were unchanged. Infections mainly occurred in the third week after surgery and were polymicrobial.
AB - Objectives: To determine whether groin dissection surgical site infection (SSI) incidence changed with shorter post-operative antibiotic prophylaxis. Background: Post-operative prophylaxis changed due to antimicrobial stewardship, from regular oral antibiotics until drain removal, to three intravenous doses. Both groups had a single intravenous dose at induction. Methods: A prospective database of groin dissections for metastatic skin cancer was retrospectively reviewed for SSI according to Public Health England criteria. Eighty groin dissections in 79 consecutive patients were included: 40 had oral antibiotics until drain removal [mean 26±7 (range 19–36) days] and 39 had three post-operative intravenous doses. Results: Longer prophylaxis was associated with lower SSI incidence [10 (25%) versus 21 (54%), odds ratio (OR) 3.50, 95% confidence interval (CI) 1.34–9.08, p = 0.009], fewer deep infections [5 (13%) versus 16 (41%), OR 4.89, 95% CI 1.57–15.13, p = 0.004], fewer readmissions for infection [5 (13%) versus 15 (38%), OR 4.38, 95% CI 1.40–13.65, p = 0.008], but similar seroma incidence [18 (45%) versus 16 (41%), OR 0.85, 95% CI 0.35–2.07, p = 0.72] and wound dehiscence [7 (18%) versus 5 (13%), OR 0.69, 95% CI 0.20–2.40, p = 0.56]. BMI ≥30 (n = 21) was associated with SSI, occurring in 13 of 21 (62%) (OR 3.859, 95% CI 1.34–11.10, p = 0.01). Median infection onset was 22 days (IQR 12–27) versus 17 (IQR 13–22), (p = 0.53). Multiple organisms were cultured in 21 of 31 (68%) patients with positive microbiological samples. Conclusions: SSI rates doubled with shorter prophylaxis; deep infections and readmissions for infection tripled. Obesity was independently associated with infection. Seroma and wound dehiscence incidence were unchanged. Infections mainly occurred in the third week after surgery and were polymicrobial.
KW - Antibiotic prophylaxis
KW - Groin dissection
KW - Melanoma
KW - Metastatic cancer
KW - Skin malignancy
KW - Surgical site infection
UR - http://www.scopus.com/inward/record.url?scp=85100377558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100377558&partnerID=8YFLogxK
U2 - 10.1016/j.bjps.2020.11.035
DO - 10.1016/j.bjps.2020.11.035
M3 - Article
C2 - 33551360
AN - SCOPUS:85100377558
SN - 1748-6815
VL - 74
SP - 1553
EP - 1561
JO - Journal of Plastic, Reconstructive and Aesthetic Surgery
JF - Journal of Plastic, Reconstructive and Aesthetic Surgery
IS - 7
ER -