Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro

Fang Zheng; Steven W. Johnson

doi:10.1016/S0006-8993(02)03096-2

Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro

Fang Zheng, Steven W. Johnson

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Metabotropic glutamate receptor (mGluR) agonist t-ACPD produced concentration-dependent enhancement of NMDA/apamin-induced burst firing and membrane oscillations in dopamine cells, recorded intracellularly from ventral tegmental area in the rat midbrain slice. Such effects were blocked reversibly by mGluR antagonist MCPG, and mimicked by the selective agonist for group I (but not group II and III) mGluRs. Our results point out a selective involvement of group I mGluRs in facilitating burst firing of midbrain dopamine cells.

Original language	English (US)
Pages (from-to)	171-174
Number of pages	4
Journal	Brain research
Volume	948
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)03096-2
State	Published - Sep 6 2002
Externally published	Yes

Keywords

Dopamine cell
Metabotropic glutamate receptor
NMDA/apamin-induced burst
Ventral tegmental area

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(02)03096-2

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title = "Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro",

abstract = "Metabotropic glutamate receptor (mGluR) agonist t-ACPD produced concentration-dependent enhancement of NMDA/apamin-induced burst firing and membrane oscillations in dopamine cells, recorded intracellularly from ventral tegmental area in the rat midbrain slice. Such effects were blocked reversibly by mGluR antagonist MCPG, and mimicked by the selective agonist for group I (but not group II and III) mGluRs. Our results point out a selective involvement of group I mGluRs in facilitating burst firing of midbrain dopamine cells.",

keywords = "Dopamine cell, Metabotropic glutamate receptor, NMDA/apamin-induced burst, Ventral tegmental area",

author = "Fang Zheng and Johnson, {Steven W.}",

note = "Funding Information: This work is supported by US Public Health Service Grant MH40416.",

year = "2002",

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doi = "10.1016/S0006-8993(02)03096-2",

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T1 - Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro

AU - Zheng, Fang

AU - Johnson, Steven W.

N1 - Funding Information: This work is supported by US Public Health Service Grant MH40416.

PY - 2002/9/6

Y1 - 2002/9/6

N2 - Metabotropic glutamate receptor (mGluR) agonist t-ACPD produced concentration-dependent enhancement of NMDA/apamin-induced burst firing and membrane oscillations in dopamine cells, recorded intracellularly from ventral tegmental area in the rat midbrain slice. Such effects were blocked reversibly by mGluR antagonist MCPG, and mimicked by the selective agonist for group I (but not group II and III) mGluRs. Our results point out a selective involvement of group I mGluRs in facilitating burst firing of midbrain dopamine cells.

AB - Metabotropic glutamate receptor (mGluR) agonist t-ACPD produced concentration-dependent enhancement of NMDA/apamin-induced burst firing and membrane oscillations in dopamine cells, recorded intracellularly from ventral tegmental area in the rat midbrain slice. Such effects were blocked reversibly by mGluR antagonist MCPG, and mimicked by the selective agonist for group I (but not group II and III) mGluRs. Our results point out a selective involvement of group I mGluRs in facilitating burst firing of midbrain dopamine cells.

KW - Dopamine cell

KW - Metabotropic glutamate receptor

KW - NMDA/apamin-induced burst

KW - Ventral tegmental area

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ER -

Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro

Abstract

Keywords

ASJC Scopus subject areas

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